ArticleInternational journal of colorectal disease2016
Association between diverticular disease and Ehlers-Danlos syndrome: a 13-year nationwide population-based cohort study.
Article in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Structural Alterations in Diverticular Disease.Clinics in colon and rectal surgery · 2025Review
- Diverticulitis Management in Complex Medical Contexts.Clinics in colon and rectal surgery · 2025Review
- Understanding the Natural History of the Disease.Seminars in colon & rectal surgery · 2021Article
- Colonic Diverticulosis. Is there a Genetic Component?Maedica · 2020Article
- Solitary Cecal Diverticulitis Mimicking Acute Appendicitis in a Child: Intraoperative Diagnosis.Sisli Etfal Hastanesi tip bulteni · 2019Article
- Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease.Nature genetics · 2018Article
- Sampling strategies for selecting general population comparison cohorts.Clinical epidemiology · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to examine occurrence and consequences of diverticular disease in patients with Ehlers-Danlos syndrome (EDS) compared with a matched cohort.
methodsThis nationwide population-based cohort study was conducted using data from medical registers in Denmark from year 2000 to 2012. The EDS cohort was identified using the specific diagnosis code for EDS and was randomly matched in a ratio of 1:20 by sex and date of birth (±1 year) with persons from the Danish general population. The occurrence of diverticular disease and the clinical characteristics of the initial diverticular event were compared between the EDS cohort and the comparison cohort. The first admission with diverticulitis was identified, and severity of diverticulitis, treatment, colonoscopies, length of stay, and 30-day mortality were investigated.
resultsWe identified 1336 patients with EDS and matched a control cohort of 26,720 patients. The occurrence of diverticular disease in the EDS cohort (2.0 %) and the comparison cohort (0.68 %) differed significantly (p < 0.001). At the first diverticular event, the majority of patients were women (85 % for EDS and 87 % for the comparison cohort). Mean age, localization, and type of contact did not differ significantly. Admission with diverticulitis (1.0 % for EDS and 0.34 % for the comparison cohort) differed significantly (p < 0.001). We found no significant difference in severity of diverticulitis, treatment, length of stay, or 30-day mortality between the EDS and the comparison cohorts.
conclusionsPatients with EDS had an increased occurrence of overall diverticular events and admissions with diverticulitis compared with the general population.
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