Evidence map›Paper›PMID 27604798›Full record

ArticleThe Korean journal of internal medicine2016

Relationship between pulmonary function and bone mineral density in the Korean National Health and Nutrition Examination Survey.

In Seon Lee, Ah Young Leem, Sang Hoon Lee, Yumie Rhee, Yoon Ha, Young Sam Kim

Open access · goldAbstract read
In one paragraph

Article in The Korean journal of internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Guideline
  2. Sarcopenia in COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2019
    Pooled it
  3. Managing Osteoporosis in COPD.Endocrine, metabolic & immune disorders drug targets · 2024
    Review
  4. Effect of pulmonary function on bone mineral density in the United States: results from the NHANES 2007-2010 study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Article
  5. Article
  6. Article
  7. Addiction-Associated Genetic Variants Implicate Brain Cell Type- and Region-Specific Cis-Regulatory Elements in Addiction Neurobiology.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

In Seon LeeDivision of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Ah Young LeemDivision of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Sang Hoon LeeDivision of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Yumie RheeDepartment of Internal Medicine, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Yoon HaDepartment of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Young Sam KimDivision of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Yonsei University · KRSeverance Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsOsteoporosis is common in chronic obstructive pulmonary disease (COPD) patients. The relationship between osteoporosis and COPD has been primarily reported in patients with moderate to severe COPD, but there is no report in the general population. The aim of this study is to investigate the relationship between bone mineral density (BMD) and lung function in the general Korean population.

methodsThis study was based on data acquired from the Fourth and Fifth Korea National Health and Nutrition Examination Surveys (KNHANES IV and V), conducted from 2008 to 2010. The study population included 4,501 subjects (aged ≥ 50 years) who underwent both spirometry and BMD. The study populations were divided into two groups by sex to correct for the effects of gender on BMD. All female participants were postmenopausal women.

resultsThe BMD values of the femur neck, total femur, and L-spine tended to decrease with degree of airflow limitation in both genders. To correct confounding factors, data were analyzed and adjusted for age, body mass index, fat free mass index, body fat percentage, smoking amount, parathyroid hormone levels, daily calcium and phosphorus intake, and alkaline phosphatase (ALP) levels. While the BMD of the femur neck, total femur, and L-spine was reduced significantly as age and ALP increased, the correlation between airway obstruction and BMD of all regions disappeared in both genders.

conclusionsIn the general population aged 50 years and older, diminution of BMD is not associated with airway obstruction. Further investigation along other factors is needed to determine the possible role of pulmonary function and BMD.

Indexed as

AgedAged, 80 and overBone DensityCross-Sectional StudiesFemaleHumansLungMaleMiddle AgedNutrition SurveysOsteoporosisPulmonary Disease, Chronic ObstructiveRepublic of KoreaRespiratory Function TestsBone densityOsteoporosisRespiratory function tests

Identifiers

PMID27604798
PMCPMC5016283
OpenAlexW2513648660

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.