ArticleAlimentary pharmacology & therapeutics2016
Early primary biliary cholangitis is characterised by brain abnormalities on cerebral magnetic resonance imaging.
Article in Alimentary pharmacology & therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- L-Carnitine in the Treatment of Psychiatric and Neurological Manifestations: A Systematic Review.Nutrients · 2024Pooled it
- Thalamic homeostatic transcriptomic signatures are altered in a mouse model of cholestatic liver injury and are mitigated by systemic TNF neutralization.Molecular brain · 2026Article
- Genetic evidence supports primary biliary cholangitis as a risk factor for lacunar stroke.iScience · 2025Article
- Golexanolone Attenuates Neuroinflammation, Fatigue, and Cognitive and Motor Impairment in Diverse Neuroinflammatory Disorders.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Identification of secretory protein related biomarkers for primary biliary cholangitis based on machine learning and experimental validation.Open life sciences · 2025Article
- Integrative bioinformatics analysis and experimental validation of key biomarkers for risk stratification in primary biliary cholangitis.Arthritis research & therapy · 2023Article
- Diabetes mellitus - risk factor and potential future target for hepatic encephalopathy in patients with liver cirrhosis?Metabolic brain disease · 2023Review
- Anti-Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct-Ligated Mice.The American journal of pathology · 2023Article
- Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?Canadian journal of gastroenterology & hepatology · 2022Article
- Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management.Przeglad gastroenterologiczny · 2022Review
- Understanding Fatigue in Primary Biliary Cholangitis.Digestive diseases and sciences · 2021Article
- Current understanding of primary biliary cholangitis.Clinical and molecular hepatology · 2021Review
- Article
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundBrain change can occur in primary biliary cholangitis (PBC), potentially as a result of cholestatic and/or inflammatory processes. This change is linked to systemic symptoms of fatigue and cognitive impairment.
aimTo identify whether brain change occurs early in PBC. If the change develops early and is progressive, it may explain the difficulty in treating these symptoms.
methodsEarly disease brain change was explored in 13 patients with newly diagnosed biopsy-proven precirrhotic PBC using magnetisation transfer, diffusion-weighted imaging and
resultsCerebral magnetisation transfer ratios were reduced in early PBC, compared to healthy volunteers, in the thalamus, putamen and head of caudate with no greater reduction in patients with greater symptom severity. Mean apparent diffusion coefficients were increased in the thalamus only. No
conclusionsThis is the first study to be performed in this precirrhotic patient population, and we have highlighted that neuroimaging changes are present at a much earlier stage than previously demonstrated. The neuroimaging abnormalities suggest that the brain changes seen in PBC occur early in the pathological process, even before significant liver damage has occurred. If such changes are linked to symptom pathogenesis, this could have important implications for the timing of second-line-therapy use.
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