ArticleMagnetic resonance in medicine2017
MR imaging of a novel NOE-mediated magnetization transfer with water in rat brain at 9.4 T.
Article in Magnetic resonance in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46 citing papers in PubMed, 62 citations in OpenAlex.
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- Toward quantitative CEST imaging of glutamate in the mouse brain using a multi-pool exchange model calibrated byMagnetic resonance in medicine · 2025Article
- Improving quantification accuracy of a nuclear Overhauser enhancement signal at -1.6 ppm at 4.7 T using a machine learning approach.Physics in medicine and biology · 2025Article
- A Denoising Convolutional Autoencoder for SNR Enhancement in Chemical Exchange Saturation Transfer imaging: (DCAE-CEST).bioRxiv : the preprint server for biology · 2024Article
- Machine learning-based amide proton transfer imaging using partially synthetic training data.Magnetic resonance in medicine · 2024Article
- Specific and rapid guanidinium CEST imaging using double saturation power and QUASS analysis in a rodent model of global ischemia.Magnetic resonance in medicine · 2024Article
- Nuclear Overhauser enhancement imaging at -1.6 ppm in rat brain at 4.7T.Magnetic resonance in medicine · 2024Article
- Article
- Investigation of relayed nuclear Overhauser enhancement effect at -1.6 ppm in an ischemic stroke model.Quantitative imaging in medicine and surgery · 2023Article
- Validation of the presence of fast exchanging amine CEST effect at low saturation powers and its influence on the quantification of APT.Magnetic resonance in medicine · 2023Article
- Isolation of amide proton transfer effect and relayed nuclear Overhauser enhancement effect at -3.5ppm using CEST with double saturation powers.Magnetic resonance in medicine · 2023Article
- Evaluation of contributors to amide proton transfer-weighted imaging and nuclear Overhauser enhancement-weighted imaging contrast in tumors at a high magnetic field.Magnetic resonance in medicine · 2023Article
- Assignment of molecular origins of NOE signal at -3.5 ppm in the brain.Magnetic resonance in medicine · 2023Article
- In vivo reproducibility of 3D relayed NOE in the healthy human brain at 7 T.Magnetic resonance in medicine · 2023Article
- Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) quantification of transient ischemia using a combination method of 5-pool Lorentzian fitting and inverse Z-spectrum analysis.Quantitative imaging in medicine and surgery · 2023Article
- NOE-weighted imaging in tumors using low-duty-cycle 2π-CEST.Magnetic resonance in medicine · 2023Article
- Noninvasively differentiating acute and chronic nephropathies via multiparametric urea-CEST, nuclear Overhauser enhancement-CEST, and quantitative magnetization transfer MRI.Magnetic resonance in medicine · 2023Article
- In vivo pH mapping with omega plot-based quantitative chemical exchange saturation transfer MRI.Magnetic resonance in medicine · 2023Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo detect, map, and quantify a novel nuclear Overhauser enhancement (NOE)-mediated magnetization transfer (MT) with water at approximately -1.6 ppm [NOE(-1.6)] in rat brain using MRI.
methodsContinuous wave MT sequences with a variety of radiofrequency irradiation powers were optimized to achieve the maximum contrast of this NOE(-1.6) effect at 9.4 T. The distribution of effect magnitudes, resonance frequency offsets, and line widths in healthy rat brains and the differences of the effect between tumors and contralateral normal brains were imaged and quantified using a multi-Lorentzian fitting method. MR measurements on reconstituted model phospholipids as well as two cell lines (HEK293 and 9L) were also performed to investigate the possible molecular origin of this NOE.
resultsOur results suggest that the NOE(-1.6) effect can be detected reliably in rat brain. Pixel-wise fittings demonstrated the regional variations of the effect. Measurements in a rodent tumor model showed that the amplitude of NOE(-1.6) in brain tumor was significantly diminished compared with that in normal brain tissue. Measurements of reconstituted phospholipids suggest that this effect may originate from choline phospholipids.
conclusionNOE(-1.6) could be used as a new biomarker for the detection of brain tumor. Magn Reson Med 78:588-597, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
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