ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Prior Cocaine Experience Impairs Normal Phasic Dopamine Signals of Reward Value in Accumbens Shell.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- The nucleus accumbens in reward and aversion processing: insights and implications.Frontiers in behavioral neuroscience · 2024Review
- Nucleus accumbens shell dopamine mediates outcome value, but not predicted value, in a magnitude decision-making task.The European journal of neuroscience · 2020Article
- Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion.Neurochemistry international · 2019Review
- Topography of Reward and Aversion Encoding in the Mesolimbic Dopaminergic System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Contributions of nucleus accumbens dopamine to cognitive flexibility.The European journal of neuroscience · 2019Article
- Previous cocaine self-administration disrupts reward expectancy encoding in ventral striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Not worth the wait: cocaine alters reward processing in the nucleus accumbens.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Heterogeneous dopamine signals support distinct features of motivated actions: implications for learning and addiction.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- The impact of drugs of abuse on executive function: characterizing long-term changes in neural correlates following chronic drug exposure and withdrawal in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Nucleus Accumbens Modulation in Reward and Aversion.Cold Spring Harbor symposia on quantitative biology · 2018Article
- Hitchhiker's Guide to Voltammetry: Acute and Chronic Electrodes for in Vivo Fast-Scan Cyclic Voltammetry.ACS chemical neuroscience · 2017Review
- Cross-talk between the epigenome and neural circuits in drug addiction.Progress in brain research · 2017Review
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Authors and funding
3 authors.
Funding
Abstract
Dopamine signals have repeatedly been linked to associative learning and motivational processes. However, there is considerably less agreement on a role for dopamine in reward processing, and therefore whether neuroplastic changes in dopamine function following chronic exposure to drugs of abuse such as cocaine may impair appropriate valuation of rewarding stimuli. To quantify this, we voltammetrically measured real-time dopamine release in the nucleus accumbens (NAc) core or shell while rats received unsignaled deliveries of either a small (1 pellet) or large (2 pellets) reward. In drug-naive controls, core dopamine signals did not discriminate between reward size at any point, while in the shell dopamine encoded magnitude differences only in a slower postpeak period. Despite this lack of discrimination between rewards by the peak DA response, controls easily discriminated between reward options in a subsequent choice task. In contrast, phasic dopamine reward signals were strongly altered by cocaine experience; core dopamine decreased peak response but increased discrimination between reward magnitudes while shell lost phasic responses to reward receipt altogether. Notably, animals with cocaine-associated alterations in dopamine signals for reward magnitude failed to subsequently discriminate between reward options. These findings suggest that cocaine self-administration alters the ability for dopamine signals to appropriately assign value to rewards and thus may in part contribute to later deficits in behaviors that depend on appropriate outcome valuation.
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