ArticlePhysiological reports2016
The effect of acute and chronic sprint-interval training on LRP130, SIRT3, and PGC-1α expression in human skeletal muscle.
Article in Physiological reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- The role of exercise in modulating NAD+ metabolic enzymes: mechanisms and health benefits.Frontiers in sports and active living · 2026Review
- Mitochondrial and cardiovascular responses to aerobic exercise training in supine and upright positions in healthy young adults: a randomized parallel arm trial.Translational exercise biomedicine · 2025Article
- Heat acclimation improves exercise performance in hot conditions and increases heat shock protein 70 and 90 of skeletal muscles in Thoroughbred horses.Physiological reports · 2024Article
- Aerobic Exercise Improves Depressive-like Behavior in CUMS-Induced Rats via the SIRT3/ROS/NLRP3 Signaling Pathway.Life (Basel, Switzerland) · 2023Article
- Sex differences in muscle SIRT1 and SIRT3 and exercise + weight loss effects on muscle sirtuins.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- The Role of SIRT3 in Exercise and Aging.Cells · 2022Review
- Physiological Responses to Low-Volume Interval Training in Women.Sports medicine - open · 2021Review
- Review
- Increasing whole-body energetic stress does not augment fasting-induced changes in human skeletal muscle.Pflugers Archiv : European journal of physiology · 2021Article
- Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology.Frontiers in physiology · 2021Review
- Fiber-specific and whole-muscle LRP130 expression in rested, exercised, and fasted human skeletal muscle.Pflugers Archiv : European journal of physiology · 2020Article
- The impact of acute and chronic exercise on Nrf2 expression in relation to markers of mitochondrial biogenesis in human skeletal muscle.European journal of applied physiology · 2020Article
- Beneficial effects of running and milk protein supplements on Sirtuins and risk factors of metabolic disorders in rats with low aerobic capacity.Metabolism open · 2019Article
- Protein arginine methyltransferase biology in humans during acute and chronic skeletal muscle plasticity.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- An appraisal of the SDPhysiological reports · 2019Review
- Exercise and Sirtuins: A Way to Mitochondrial Health in Skeletal Muscle.International journal of molecular sciences · 2019Review
- Principles of Exercise Prescription, and How They Influence Exercise-Induced Changes of Transcription Factors and Other Regulators of Mitochondrial Biogenesis.Sports medicine (Auckland, N.Z.) · 2018Review
- Beneficial Autophagic Activities, Mitochondrial Function, and Metabolic Phenotype Adaptations Promoted by High-Intensity Interval Training in a Rat Model.Frontiers in physiology · 2018Article
- Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle.Ageing research reviews · 2017Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined changes in LRP130 gene and protein expression in response to an acute bout of sprint-interval training (SIT) and 6 weeks of SIT in human skeletal muscle. In addition, we investigated the relationships between changes in LRP130, SIRT3, and PGC-1α gene or protein expression. Fourteen recreationally active men (age: 22.0 ± 2.4 years) performed a single bout of SIT (eight, 20-sec intervals at ~170% of VO2peak work rate, separated by 10 sec of rest). Muscle biopsies were obtained at rest (PRE) and 3 h post-exercise. The same participants then underwent a 6 week SIT program with biopsies after 2 (MID) and 6 (POST) weeks of training. In response to an acute bout of SIT, PGC-1α mRNA expression increased (284%, P < 0.001); however, LRP130 and SIRT3 remained unchanged. VO2peak and fiber-specific SDH activity increased in response to training (P < 0.01). LRP130, SIRT3, and PGC-1α protein expression were also unaltered following 2 and 6 weeks of SIT There were no significant correlations between LRP130, SIRT3, or PGC-1α mRNA expression in response to acute SIT However, changes in protein expression of LRP130, SIRT3, and PGC-1α were positively correlated at several time points with large effect sizes, which suggest that the regulation of these proteins may be coordinated in human skeletal muscle. Future studies should investigate other exercise protocols known to increase PGC-1α and SIRT3 protein, like longer duration steady-state exercise, to identify if LRP130 expression can be altered in response to exercise.
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Registered trials
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