Evidence map›Paper›PMID 27604367›Full record

ArticleSurgical endoscopy2017

Endoscopic gastric atrophy is strongly associated with gastric cancer development after Helicobacter pylori eradication.

Osamu Toyoshima, Yutaka Yamaji, Shuntaro Yoshida, Shuhei Matsumoto, Hiroharu Yamashita, Takamitsu Kanazawa, Keisuke Hata

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical endoscopy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Pooled it
  5. Trial
  6. Gastritis: Pathophysiology, Diagnosis, and Clinical Implications.The Korean journal of helicobacter and upper gastrointestinal research · 2026
    Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Validation of a Novel Endoscopic Feature that PredictsThe Korean journal of helicobacter and upper gastrointestinal research · 2023
    Article
  12. [Clinical Application of the Kyoto Classification of Gastritis].The Korean journal of helicobacter and upper gastrointestinal research · 2023
    Review
  13. [Approach to Patients after Successful Eradication ofThe Korean journal of helicobacter and upper gastrointestinal research · 2023
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. How DoesInfection and drug resistance · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Osamu ToyoshimaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo, 157-0066, Japan. t@ichou.com.ORCID 0000-0002-6953-6079
Yutaka YamajiHealth Development Center, Tokyo Pharmaceutical Industry Health Insurance Society, Tokyo, Japan.
Shuntaro YoshidaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo, 157-0066, Japan.
Shuhei MatsumotoDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo, 157-0066, Japan.
Hiroharu YamashitaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo, 157-0066, Japan.
Takamitsu KanazawaDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo, 157-0066, Japan.
Keisuke HataDepartment of Gastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo, 157-0066, Japan.
The University of Tokyo · JPSeijo University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRisk factors for gastric cancer during continuous infection with Helicobacter pylori have been well documented; however, little has been reported on the risk factors for primary gastric cancer after H. pylori eradication. We conducted a retrospective, endoscopy-based, long-term, large-cohort study to clarify the risk factors for gastric cancer following H. pylori eradication.

methodsPatients who achieved successful H. pylori eradication and periodically underwent esophagogastroduodenoscopy surveillance thereafter at Toyoshima Endoscopy Clinic were enrolled. The primary endpoint was the development of gastric cancer. Statistical analysis was performed using the Kaplan-Meier method and Cox's proportional hazards models.

resultsGastric cancer developed in 15 of 1232 patients. The cumulative incidence rates were 1.0 % at 2 years, 2.6 % at 5 years, and 6.8 % at 10 years. Histology showed that all gastric cancers (17 lesions) in the 15 patients were of the intestinal type, within the mucosal layer, and <20 mm in diameter. Based on univariate analysis, older age and higher endoscopic grade of gastric atrophy were significantly associated with gastric cancer development after eradication of H. pylori, and gastric ulcers were marginally associated. Multivariate analysis identified higher grade of gastric atrophy (hazard ratio 1.77; 95 % confidence interval 1.12-2.78; P = 0.01) as the only independently associated parameter.

conclusionsEndoscopic gastric atrophy is a major risk factor for gastric cancer development after H. pylori eradication. Further long-term studies are required to determine whether H. pylori eradication leads to regression of H. pylori-related gastritis and reduces the risk of gastric cancer.

Indexed as

AtrophyEndoscopy, Digestive SystemFemaleFollow-Up StudiesHelicobacter InfectionsHelicobacter pyloriHumansJapanMaleMiddle AgedRetrospective StudiesRisk FactorsStomachStomach NeoplasmsAtrophic gastritisChemopreventionEndoscopyHelicobacter pyloriRisk factorsStomach neoplasms

Identifiers

PMID27604367
PMCPMC5411409
OpenAlexW2518082296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.