ArticleBrain : a journal of neurology2016
Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations.
Registry-linked trialAbstract read
In one paragraph
Article in Brain : a journal of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02723448 (A Pilot Study of Aclarubicin for the Treatment of Retinal Vasculopathy With Cerebral Leukodystrophy), which is not on this map. Cited by 67 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Study of Aclarubicin for the Treatment of Retinal Vasculopathy With Cerebral Leukodystrophy (RVCL)
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of prognostic biomarkers in neonatal retinal hemorrhage.International ophthalmology · 2022Pooled it
- Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study.The Journal of clinical investigation · 2024Trial
- Headache Attributed to Genetic Vasculopathies.Current pain and headache reports · 2026Review
- Autoinflammatory syndromes of STING and TREX1 dysfunction.The Journal of clinical investigation · 2026Review
- Neuroimaging Biomarkers of Disease Progression and Cognitive Change in Patients With Retinal Vasculopathy With Cerebral Leukoencephalopathy.Neurology · 2026Article
- Retinal Vasculopathy With Cerebral Leukoencephalopathy Mimicking a Brain Tumor: A Case Report.Cureus · 2026Article
- First case ofFrontiers in immunology · 2026Article
- One year follow up in siblings with TREX1-associated retinal vasculopathy with cerebral leukodystrophy.American journal of ophthalmology case reports · 2025Article
- Article
- A case of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations.Radiology case reports · 2025Article
- Misdirected yet intact TREX1 exonuclease activity causes human cerebral and systemic small vessel disease.Brain : a journal of neurology · 2025Article
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- Migraine with and without aura-two distinct entities? A narrative review.The journal of headache and pain · 2025Review
- Monogenic causes of cerebral small vessel disease- models for vascular cognitive impairment and dementia?Current opinion in psychiatry · 2025Review
- Longitudinal association of retinal morphology and white matter progression in retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations.Frontiers in neurology · 2025Article
- The intersection of TREX1, cGAS, STING and the DNA damage theory of aging.Frontiers in aging · 2025Review
- Prime Editor Gene Therapy and TREX1 Mosaicism in Retinal Vasculopathy with Cerebral Leukoencephalopathy.Journal of clinical immunology · 2024Article
- Targeting the P-selectin/PSGL-1 pathway: discovery of disease-modifying therapeutics for disorders of thromboinflammation.Blood vessels, thrombosis & hemostasis · 2024Review
- Overview of Neuro-Ophthalmic Findings in Leukodystrophies.Journal of clinical medicine · 2024Article
- Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations in conjunction with systemic lupus erythematosus: Missed diagnosis or misdiagnosis?Immunity, inflammation and disease · 2024Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
37 authors.
Anine H StamDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Parul H KothariDepartment of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Aisha ShaikhDepartment of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Andreas GschwendterInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians Universität, D-81377 München, Germany.
Joanna C JenDepartment of Neurology, University of California at Los Angeles, Los Angeles, California 90095, USA.
Suzanne HodgkinsonDepartment of Neurology, Liverpool Hospital, Liverpool, New South Wales 2170, Australia.
Todd A HardyDepartment of Neurology, Concord Repatriation General Hospital, Concord, New South Wales 2139, Australia.
Michael HayesDepartment of Neurology, Concord Repatriation General Hospital, Concord, New South Wales 2139, Australia.
Peter A KempsterNeurosciences Department, Monash Medical Centre, Clayton, Victoria 3168, Australia.
Katya E KotschetNeurosciences Department, Monash Medical Centre, Clayton, Victoria 3168, Australia.
Ingeborg M BajemaDepartment of Pathology, Leiden University Medical Centre, Leiden, The Netherlands.
Sjoerd G van DuinenDepartment of Pathology, Leiden University Medical Centre, Leiden, The Netherlands.
Marion L C Maat-SchiemanDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Paulus T V M de JongDepartment of Ophthalmology, Academic Medical Centre, 1100 DD Amsterdam, The Netherlands.
Marc D de SmetDepartment of Ophthalmology, Academic Medical Centre, 1100 DD Amsterdam, The Netherlands.
Didi de Wolff-RouendaalDepartment of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands.
Greet DijkmanDepartment of Ophthalmology, Leiden University Medical Centre, Leiden, The Netherlands.
Nadine PelzerDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Grant R KolarDepartment of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Robert E SchmidtDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, 63110 USA.
JoAnne LaceyWest County Radiology Group, Mercy Hospital in St Louis, MO 63141, USA.
Daniel JosephThe Retina Institute, Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri, 63110 USA.
David R FintakThe Retina Institute, Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri, 63110 USA.
M Gilbert GrandThe Retina Institute, Department of Ophthalmology, Washington University School of Medicine, St. Louis, Missouri, 63110 USA.
Elizabeth M BruntDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, 63110 USA.
Helen LiapisDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, 63110 USA.
Rula A Hajj-AliDepartment of Rheumatic and Immunologic Disease, Cleveland Clinic, Cleveland, Ohio, 44195 USA.
Mark C KruitDepartment of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
Mark A van BuchemDepartment of Radiology, Leiden University Medical Centre, Leiden, The Netherlands.
Martin DichgansInstitute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians Universität, D-81377 München, Germany.
Rune R FrantsDepartment of Human Genetics, Leiden University Medical Centre, Leiden, The Netherlands.
Arn M J M van den MaagdenbergDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Joost HaanDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Robert W BalohDepartment of Neurology, University of California at Los Angeles, Los Angeles, California 90095, USA.
John P AtkinsonDepartment of Medicine, Division of Rheumatology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Gisela M TerwindtDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Michel D FerrariDepartment of Neurology, Leiden University Medical Centre, Leiden, The Netherlands.
Funding
Pathobiology of Retinal Vasculopathy with Cerebal Leukodystrophy (RVCL)R01NS062069 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JEN, JOANNA C · 2009 to 2010
$1.1MNIH HHS HL083822NIH HHS R01 NS062069
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultCADASILFemaleHumansLeukoencephalopathiesMaleMiddle AgedRetinal Vasculitismigrainemolecular geneticsneuro-ophthalmologyneuropathologysmall vessel disease
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT02723448ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.