ArticleNeurogenesis (Austin, Tex.)2015
The Purkinje neuron: A central orchestrator of cerebellar neurogenesis.
Article in Neurogenesis (Austin, Tex.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum.Cerebellum (London, England) · 2024Review
- Chorioamnionitis accelerates granule cell and oligodendrocyte maturation in the cerebellum of preterm nonhuman primates.Journal of neuroinflammation · 2024Article
- Neonatal subarachnoid hemorrhage disrupts multiple aspects of cerebellar development.Frontiers in molecular neuroscience · 2023Article
- Endoglycan Regulates Purkinje Cell Migration by Balancing Cell-Cell Adhesion.Frontiers in neuroscience · 2022Article
- Article
- Intrauterine growth restriction compromises cerebellar development by affecting radial migration of granule cells via the JamC/Pard3a molecular pathway.Experimental neurology · 2021Article
- Cerebellar nuclei evolved by repeatedly duplicating a conserved cell-type set.Science (New York, N.Y.) · 2020Article
- Mosaic Analysis with Double Markers reveals IGF1R function in granule cell progenitors during cerebellar development.Developmental biology · 2020Article
- Article
- What cerebellar malformations tell us about cerebellar development.Neuroscience letters · 2019Review
- Embryology.Handbook of clinical neurology · 2018Review
- Large-scale structural alteration of brain in epileptic children withNeuroImage. Clinical · 2017Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Within the cyto-architecture of the brain is an often complex, but balanced, neuronal circuitry, the successful construction of which relies on the coordinated generation of functionally opposed neurons. Indeed, deregulated production of excitatory/inhibitory interneurons can greatly disrupt the integrity of excitatory/inhibitory neuronal transmission, which is a hallmark of neurodevelopmental disorders such as autism. Recent work has demonstrated that the Purkinje neuron, the central integrator of signaling within the cerebellar system, acts during development to ensure that neurogenesis occurring in spatially opposed domains reaches completion by transmitting the Sonic hedgehog ligand bi-directionally. In addition to a classic role in driving granule cell precursor proliferation, we now know that Purkinje neuron-derived Sonic hedgehog is simultaneously disseminated to the neonatal white matter. Within this neurogenic niche a lineage of Shh-responding stem and progenitor cells expand pools of GABAergic interneuron and astrocyte precursors. These recent findings advance our understanding of how Purkinje neurons function dynamically to oversee completion of a balanced cerebellar circuit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.