ArticleScientific reports2016
CollagenVI-Cre mice: A new tool to target stromal cells in secondary lymphoid organs.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- IL1R1Nature communications · 2023Article
- Col6a1Cellular and molecular life sciences : CMLS · 2021Article
- Stromal cell-derived DEL-1 inhibits Tfh cell activation and inflammatory arthritis.The Journal of clinical investigation · 2021Article
- Differentiation and activation of fibroblastic reticular cells.Immunological reviews · 2021Review
- Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity.Nature immunology · 2021Article
- Fibroblastic reticular cells at the nexus of innate and adaptive immune responses.Immunological reviews · 2019Review
- The circadian regulator Bmal1 in joint mesenchymal cells regulates both joint development and inflammatory arthritis.Arthritis research & therapy · 2019Article
- Intrinsic Control of Surface Immune and Epithelial Homeostasis by Tissue-Resident Gut Stromal Cells.Frontiers in immunology · 2019Review
- Comorbid TNF-mediated heart valve disease and chronic polyarthritis share common mesenchymal cell-mediated aetiopathogenesis.Annals of the rheumatic diseases · 2018Article
- Mesenchymal TNFR2 promotes the development of polyarthritis and comorbid heart valve stenosis.JCI insight · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Stromal cells in secondary lymphoid organs (SLOs) are non-hematopoietic cells involved in the regulation of adaptive immune responses. Three major stromal populations have been identified in adult SLOs: fibroblastic reticular cells (FRCs), follicular dendritic cells (FDCs) and marginal reticular cells (MRCs). The properties of these individual populations are not clearly defined, mainly due to the lack of appropriate genetic tools, especially for MRCs. Here, we analyzed stromal cell targeting in SLOs from a transgenic mouse strain that expresses Cre recombinase under the CollagenVI promoter, using lineage tracing approaches. We show that these mice target specifically MRCs and FDCs, but not FRCs in Peyer's patches and isolated lymphoid follicles in the intestine. In contrast, stromal cells in lymph nodes and the spleen do not express the transgene, which renders ColVI-cre mice ideal for the specific targeting of stromal cells in the gut-associated lymphoid tissue (GALT). This funding further supports the hypothesis of organ-specific stromal precursors in SLOs. Interestingly, in all tissues analyzed, there was also high specificity for perivascular cells, which have been proposed to act as FDC precursors. Taken together, ColVI-Cre mice are a useful new tool for the dissection of MRC- and FDC-specific functions and plasticity in the GALT.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.