ArticleBrain connectivity2016
Hemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait.
Article in Brain connectivity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- The effect of task complexity on the neural network for response inhibition: An ALE meta-analysis.Neuroscience and biobehavioral reviews · 2024Pooled it
- Does losing money truly hurt? The shared neural bases of monetary loss and pain.Human brain mapping · 2022Pooled it
- The neural underpinnings of intergroup social cognition: an fMRI meta-analysis.Social cognitive and affective neuroscience · 2021Pooled it
- Neural correlates of altered loss aversion in alcohol use disorder: preliminary evidence of sex-related differences from 18F-FDG-PET imaging.Frontiers in psychiatry · 2026Article
- Cerebral microstructural alteration patterns in motor subtypes of Parkinson's disease: a neurite orientation dispersion and density imaging study.Quantitative imaging in medicine and surgery · 2025Article
- Epigenetic manipulation of anterior insular cortex alters neural signals and cognitive control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Article
- Increased Modulation of Low-Frequency Cardiac Rhythms on Resting-State Left Insula Alpha Oscillations in Major Depressive Disorder: Evidence from a Magnetoencephalography Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neural correlates of executive dysfunction in alcohol use disorder: preliminary evidence fromFrontiers in psychology · 2025Article
- In humans, insulo-striate structural connectivity is largely biased toward either striosome-like or matrix-like striatal compartments.bioRxiv : the preprint server for biology · 2024Article
- Neural asymmetry in aligning with generous versus selfish descriptive norms in a charitable donation task.Scientific reports · 2024Article
- In Humans, Insulo-striate Structural Connectivity is Largely Biased Toward Either Striosome-like or Matrix-like Striatal Compartments.Neuroscience insights · 2024Article
- Sleep Deficits Inter-Link Lower Basal Forebrain-Posterior Cingulate Connectivity and Perceived Stress and Anxiety Bidirectionally in Young Men.The international journal of neuropsychopharmacology · 2023Article
- Somatotopic disruption of the functional connectivity of the primary sensorimotor cortex in complex regional pain syndrome type 1.Human brain mapping · 2023Article
- Intrinsic functional clustering of the macaque insular cortex.Frontiers in integrative neuroscience · 2023Article
- Musical Experience Relates to Insula-Based Functional Connectivity in Older Adults.Brain sciences · 2022Article
- Alcohol use disorder-associated structural and functional characteristics of the insula.Journal of neuroscience research · 2022Article
- Lateralization of Resting-State Networks in Children: Association with Age, Sex, Handedness, Intelligence Quotient, and Behavior.Brain connectivity · 2022Article
- Positive alcohol expectancy and resting-state functional connectivity of the insula in problem drinking.Drug and alcohol dependence · 2022Article
- Nigral Iron Deposition Influences Disease Severity by Modulating the Effect of Parkinson's Disease on Brain Networks.Journal of Parkinson's disease · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Resting-state functional connectivity (rsFC) is widely used to examine cerebral functional organization. The imaging literature has described lateralization of insula activations during cognitive and affective processing. Evidence appears to support a role of the right-hemispheric insula in attentional orientation to salient stimulus, interoception, and physiological arousal, and a role of the left-hemispheric insula in cognitive and affective control, as well as perspective taking. In this study, in a large data set of healthy adults, we examined lateralization of the rsFC of the anterior insula (AI) by computing a laterality index (LI) of connectivity with 54 regions from the Automated Anatomic Labeling atlas. At a corrected threshold (p < 0.001), the AI is left lateralized in connectivity with the dorsomedial prefrontal cortex, superior frontal gyrus, inferior frontal cortex, and posterior orbital gyrus and right lateralized in connectivity with the postcentral gyrus, supramarginal gyrus, and superior parietal lobule. In gender differences, women, but not men, showed right-lateralized connectivity to the thalamus. Furthermore, in a subgroup of participants assessed by the tridimensional personality questionnaire, novelty seeking is correlated with the extent of left lateralization of AI connectivity to the pallidum and putamen in men and with the extent of right lateralization of AI connectivity to the parahippocampal gyrus in women. These findings support hemispheric functional differentiation of the AI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.