Evidence map›Paper›PMID 27604070›Full record

Trial reportJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017

Reducing Undercarboxylated Osteocalcin With Vitamin K Supplementation Does Not Promote Lean Tissue Loss or Fat Gain Over 3 Years in Older Women and Men: A Randomized Controlled Trial.

M Kyla Shea, Bess Dawson-Hughes, Caren M Gundberg, Sarah L Booth

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Vitamin K: Infection, Inflammation, and Auto-Immunity.Journal of inflammation research · 2024
    Review
  7. Sarcopenia in chronic kidney disease: from bench to bedside.The Korean journal of internal medicine · 2023
    Review
  8. Review
  9. Role of Vitamin K in Bone and Muscle Metabolism.Calcified tissue international · 2023
    Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Multifaceted interaction of bone, muscle, lifestyle interventions and metabolic and cardiovascular disease: role of osteocalcin.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

M Kyla SheaUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Bess Dawson-HughesUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Caren M GundbergYale University School of Medicine, New Haven, CT, USA.
Sarah L BoothUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Tufts University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Vitamin K: vascular calcification and age-related bone *R01HL069272 · NHLBI · TUFTS UNIVERSITY BOSTON · PI BOOTH, SARAH LOUISE · 2001 to 2004
$1.0M
Identifying Vitamin K Dependent Pathways in Osteoarthritis ProgressionK01AR063167 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SHEA, MARY KYLA · 2012 to 2015
$455k
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL069272NIAMS NIH HHS K01 AR063167
6 · The paper itself

Abstract

Osteocalcin (OC) is a vitamin K-dependent protein synthesized during bone formation. Mice injected with the undercarboxylated form of OC (ucOC) had more skeletal muscle mass and less fat mass than sham-treated controls, suggesting a unique metabolic role for ucOC. UcOC decreases in response to vitamin K supplementation. Our objective was to determine the effect of reducing ucOC on change in lean tissue and fat mass in older community-dwelling adults (n = 401, mean ± SD 69 ± 6 years) using data from a randomized controlled trial of vitamin K supplementation. Over 3 years, serum ucOC was reduced by 58% in women and by 61% in men randomized to vitamin K, whereas in the control group, ucOC decreased by 1% in women and 4% in men (supplementation*time p < 0.001 in men and women). However, there were no differences in the change in appendicular lean mass (calculated as arm lean mass + leg lean mass) or total body fat mass between women randomized to vitamin K and control over 3 years (supplementation*time p values all ≥ 0.18) or between men randomized to vitamin K and control (supplementation*time p values all ≥ 0.54). Consistent with these findings, ucOC was not associated cross-sectionally with appendicular lean mass or fat mass in men or women after adjustment for total OC at baseline (all p ≥ 0.12). These findings indicate the undercarboxylated form of OC is not implicated in age-related changes in skeletal muscle or adipose tissue mass in older community-dwelling adults. © 2016 American Society for Bone and Mineral Research.

Indexed as

AdiposityDietary SupplementsAgedAged, 80 and overFemaleHumansMaleMiddle AgedOsteocalcinThinnessVitamin KOsteocalcinVitamin K

Identifiers

PMID27604070
PMCPMC5292074
OpenAlexW2516367744

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.