ArticlePloS one2016
Genomic Characterization of the Novel Aeromonas hydrophila Phage Ahp1 Suggests the Derivation of a New Subgroup from phiKMV-Like Family.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Characterization and Genome Analyses of the Novel Phages P2 and vB_AhydM-H1 TargetingPHAGE (New Rochelle, N.Y.) · 2024Article
- Novel lytic bacteriophage AhFM11 as an effective therapy against hypervirulent Aeromonas hydrophila.Scientific reports · 2024Article
- A NovelViruses · 2022Article
- NovelViruses · 2022Article
- Bacteriophages in the Control ofAntibiotics (Basel, Switzerland) · 2022Review
- Phage Therapy as a Focused Management Strategy in Aquaculture.International journal of molecular sciences · 2021Review
- Bacteriophages with Potential to InactivateAntibiotics (Basel, Switzerland) · 2021Article
- Article
- Characterization of Novel Bacteriophage AhyVDH1 and Its Lytic Activity Against Aeromonas hydrophila.Current microbiology · 2021Article
- Adsorption Sequencing as a Rapid Method to Link Environmental Bacteriophages to Hosts.iScience · 2020Article
- The Podovirus ϕ80-18 Targets the Pathogenic American Biotype 1B Strains ofFrontiers in microbiology · 2020Article
- Novel Bacteriophages Capable of Disrupting Biofilms From Clinical Strains ofFrontiers in microbiology · 2020Article
- Article
- Complete genome sequences of Aeromonas and Pseudomonas phages as a supportive tool for development of antibacterial treatment in aquaculture.Virology journal · 2019Article
- Isolation and characterization of a novel, T7-like phage against Aeromonas veronii.Virus genes · 2018Article
- Characterization and diversity of phages infecting Aeromonas salmonicida subsp. salmonicida.Scientific reports · 2017Article
- Phage Therapy as a Promising New Treatment for Lung Infection Caused by Carbapenem-ResistantFrontiers in microbiology · 2017Article
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4 authors.
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Abstract
Aeromonas hydrophila is an opportunistic pathogenic bacterium causing diseases in human and fish. The emergence of multidrug-resistant A. hydrophila isolates has been increasing in recent years. In this study, we have isolated a novel virulent podophage of A. hydrophila, designated as Ahp1, from waste water. Ahp1 has a rapid adsorption (96% adsorbed in 2 min), a latent period of 15 min, and a burst size of 112 PFU per infected cell. At least eighteen Ahp1 virion proteins were visualized in SDS-polyacrylamide gel electrophoresis, with a 36-kDa protein being the predicted major capsid protein. Genome analysis of Ahp1 revealed a linear doubled-stranded DNA genome of 42,167 bp with a G + C content of 58.8%. The genome encodes 46 putative open reading frames, 5 putative phage promoters, and 3 transcriptional terminators. Based on high degrees of similarity in overall genome organization and among most of the corresponding ORFs, as well as phylogenetic relatedness among their DNAP, RNAP and major capsid proteins, we propose a new subgroup, designated Ahp1-like subgroup. This subgroup contains Ahp1 and members previously belonging to phiKMV-like subgroup, phiAS7, phi80-18, GAP227, phiR8-01, and ISAO8. Since Ahp1 has a narrow host range, for effective phage therapy, different phages are needed for preparation of cocktails that are capable of killing the heterogeneous A. hydrophila strains.
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