Evidence map›Paper›PMID 27603780›Full record

ArticlePloS one2016

Lgl1 Is Required for Olfaction and Development of Olfactory Bulb in Mice.

Zhenzu Li, Tingting Zhang, Zhuchun Lin, Congzhe Hou, Jian Zhang, Yuqin Men, Huashun Li, Jiangang Gao

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Zhenzu LiInstitute of Developmental Biology, School of Life Science, Shandong University, Jinan, 250100, Shandong, China.
Tingting ZhangInstitute of Developmental Biology, School of Life Science, Shandong University, Jinan, 250100, Shandong, China.
Zhuchun LinJinan First People's Hospital, Jinan, 250011, Shandong, China.
Congzhe HouThe Second Hospital of Shandong University, Jinan, 250000, Shandong, China.
Jian ZhangInstitute of Developmental Biology, School of Life Science, Shandong University, Jinan, 250100, Shandong, China.
Yuqin MenInstitute of Developmental Biology, School of Life Science, Shandong University, Jinan, 250100, Shandong, China.
Huashun LiSARITEX Center for Stem Cell, Engineering Translational Medicine, Shanghai East Hospital, Advanced Institute of Translational Medicine, Tongji University School of Medicine, Shanghai, 200123, China.
Jiangang GaoInstitute of Developmental Biology, School of Life Science, Shandong University, Jinan, 250100, Shandong, China.ORCID http://orcid.org/0000-0001-9048-8211
Shandong University · CNChinese Academy of Sciences · CNJinan City People's Hospital · CNSecond Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lethal giant larvae 1 (Lgl1) was initially identified as a tumor suppressor in Drosophila and functioned as a key regulator of epithelial polarity and asymmetric cell division. In this study, we generated Lgl1 conditional knockout mice mediated by Pax2-Cre, which is expressed in olfactory bulb (OB). Next, we examined the effects of Lgl1 loss in the OB. First, we determined the expression patterns of Lgl1 in the neurogenic regions of the embryonic dorsal region of the LGE (dLGE) and postnatal OB. Furthermore, the Lgl1 conditional mutants exhibited abnormal morphological characteristics of the OB. Our behavioral analysis exhibited greatly impaired olfaction in Lgl1 mutant mice. To elucidate the possible mechanisms of impaired olfaction in Lgl1 mutant mice, we investigated the development of the OB. Interestingly, reduced thickness of the MCL and decreased density of mitral cells (MCs) were observed in Lgl1 mutant mice. Additionally, we observed a dramatic loss in SP8+ interneurons (e.g. calretinin and GABAergic/non-dopaminergic interneurons) in the GL of the OB. Our results demonstrate that Lgl1 is required for the development of the OB and the deletion of Lgl1 results in impaired olfaction in mice.

Indexed as

AnimalsAnimals, NewbornBehavior, AnimalCell CountGene SilencingGlycoproteinsInterneuronsMice, Inbred C57BLMice, KnockoutMutationOlfactory BulbPAX2 Transcription FactorSmellGlycoproteinsLGL1 protein, mousePax2 protein, mousePAX2 Transcription Factor

Identifiers

PMID27603780
PMCPMC5014313
OpenAlexW2509245951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.