ArticlePloS one2016
Modelling the Dynamics of Post-Vaccination Immunity Rate in a Population of Sahelian Sheep after a Vaccination Campaign against Peste des Petits Ruminants Virus.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Prioritizing smallholder animal health needs in East Africa, West Africa, and South Asia using three approaches: Literature review, expert workshops, and practitioner surveys.Preventive veterinary medicine · 2021Pooled it
- Is PPR Epidemiological Research Addressing Global Eradication Priorities? A Scoping Review (2015-2025).Viruses · 2026Article
- Evaluating iSAT climate-informed agro-advisories for farm decisions and system performance in Senegal's drylands.Scientific reports · 2026Article
- Serosurveillance and Postvaccination Seromonitoring of Peste Des Petits Ruminants in Small Ruminants in Central Gondar Zone, Northwest Ethiopia.Transboundary and emerging diseases · 2026Article
- Assessing the Risk of Occurrence of Bluetongue in Senegal.Microorganisms · 2020Article
- Contextualized re-calculation of enteric methane emission factors for small ruminants in sub-humid Western Africa is far lower than previous estimates.Tropical animal health and production · 2019Article
- Strategies for the Global Eradication of Peste des Petits Ruminants: An Argument for the Use of Guerrilla Rather Than Trench Warfare.Frontiers in veterinary science · 2019Article
- PPR Control in a Sahelian Setting: What Vaccination Strategy for Mauritania?Frontiers in veterinary science · 2019Article
- A dynamic model of transmission and elimination of peste des petits ruminants in Ethiopia.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Ex-ante assessment of different vaccination-based control schedules against the peste des petits ruminants virus in sub-Saharan Africa.PloS one · 2018Article
- Predictive gravity models of livestock mobility in Mauritania: The effects of supply, demand and cultural factors.PloS one · 2018Article
- Towards the description of livestock mobility in Sahelian Africa: Some results from a survey in Mauritania.PloS one · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeste des petits ruminants (PPR) is an acute infectious viral disease affecting domestic small ruminants (sheep and goats) and some wild ruminant species in Africa, the Middle East and Asia. A global PPR control strategy based on mass vaccination-in regions where PPR is endemic-was recently designed and launched by international organizations. Sahelian Africa is one of the most challenging endemic regions for PPR control. Indeed, strong seasonal and annual variations in mating, mortality and offtake rates result in a complex population dynamics which might in turn alter the population post-vaccination immunity rate (PIR), and thus be important to consider for the implementation of vaccination campaigns.
methodsIn a context of preventive vaccination in epidemiological units without PPR virus transmission, we developed a predictive, dynamic model based on a seasonal matrix population model to simulate PIR dynamics. This model was mostly calibrated with demographic and epidemiological parameters estimated from a long-term follow-up survey of small ruminant herds. We used it to simulate the PIR dynamics following a single PPR vaccination campaign in a Sahelian sheep population, and to assess the effects of (i) changes in offtake rate related to the Tabaski (a Muslim feast following the lunar calendar), and (ii) the date of implementation of the vaccination campaigns.
resultsThe persistence of PIR was not influenced by the Tabaski date. Decreasing the vaccination coverage from 100 to 80% had limited effects on PIR. However, lower vaccination coverage did not provide sufficient immunity rates (PIR < 70%). As a trade-off between model predictions and other considerations like animal physiological status, and suitability for livestock farmers, we would suggest to implement vaccination campaigns in September-October. This model is a first step towards better decision support for animal health authorities. It might be adapted to other species, livestock farming systems or diseases.
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