ArticleEmerging infectious diseases2016
Increased Hospitalizations for Neuropathies as Indicators of Zika Virus Infection, according to Health Information System Data, Brazil.
Article in Emerging infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Incidence of Guillain-Barré Syndrome (GBS) in Latin America and the Caribbean before and during the 2015-2016 Zika virus epidemic: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2019Pooled it
- The global burden of climate-sensitive diseases in Brazil: the national and subnational estimates and analysis, 1990-2017.Population health metrics · 2025Article
- Article
- Effects of public health emergencies of international concern on disease control: a systematic review.Revista panamericana de salud publica = Pan American journal of public health · 2023Review
- Routine health information system in the health facilities in Yaoundé-Cameroon: assessing the gaps for strengthening.BMC medical informatics and decision making · 2020Article
- Placental Myeloid Cells Protect against Zika Virus Vertical Transmission in aJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Zika virus infection causes temporary paralysis in adult mice with motor neuron synaptic retraction and evidence for proximal peripheral neuropathy.Scientific reports · 2019Article
- Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children.Nature medicine · 2019Article
- Zika Vaccine Development-Current Progress and Challenges for the Future.Tropical medicine and infectious disease · 2019Review
- Zoonosis: Update on Existing and Emerging Vector-Borne Illnesses in the USA.Current emergency and hospital medicine reports · 2019Review
- Zika virus: Epidemiological surveillance of the Mexican Institute of Social Security.PloS one · 2019Article
- Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients.Clinical & translational immunology · 2019Article
- Impact of Zika Virus on adult human brain structure and functional organization.Annals of clinical and translational neurology · 2018Article
- Zika virus infection in the Veterans Health Administration (VHA), 2015-2016.PLoS neglected tropical diseases · 2018Article
- The Zika Virus Epidemic in Brazil: From Discovery to Future Implications.International journal of environmental research and public health · 2018Review
- Vaccines for emerging infectious diseases: Lessons from MERS coronavirus and Zika virus.Human vaccines & immunotherapeutics · 2017Review
- Increased rates of Guillain-Barré syndrome associated with Zika virus outbreak in the Salvador metropolitan area, Brazil.PLoS neglected tropical diseases · 2017Article
- Surveillance report of Zika virus among Canadian travellers returning from the Americas.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017Article
- Zika Virus Infection during Pregnancy and Congenital Abnormalities.Frontiers in microbiology · 2017Review
- Zika Virus Infection in Pregnant Women in Rio de Janeiro.The New England journal of medicine · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence is increasing that Zika virus can cause extensive damage to the central nervous system, affecting both fetuses and adults. We sought to identify traces of possible clinical manifestations of nervous system diseases among the registers of hospital admissions recorded in the Brazilian Unified Health System. Time series of several diagnoses from the International Classification of Diseases, 10th Revision, were analyzed by using control diagrams, during January 2008-February 2016. Beginning in mid-2014, we observed an unprecedented and significant rise in the hospitalization rate for congenital malformations of the nervous system, Guillain-Barré syndrome, encephalitis, myelitis, and encephalomyelitis. These conditions are compatible with viral infection and inflammation-associated manifestations and may have been due to the entrance of Zika virus into Brazil. These findings show the necessity of adequately diagnosing and treating suspected cases of Zika virus infection and also that health surveillance systems can be improved by using routine data.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.