ArticlePediatric research2016
Milk growth factors and expression of small intestinal growth factor receptors during the perinatal period in mice.
Article in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Diet at birth is critical for healthy growth, independent of effects on the gut microbiota.Microbiome · 2024Article
- Early life imprinting of intestinal immune tolerance and tissue homeostasis.Immunological reviews · 2024Review
- Developmental Stage, Solid Food Introduction, and Suckling Cessation Differentially Influence the Comaturation of the Gut Microbiota and Intestinal Epithelium in Rabbits.The Journal of nutrition · 2022Article
- Rat Milk and Plasma Immunological Profile throughout Lactation.Nutrients · 2021Article
- Maternal Programming of Social Dominance via Milk Cytokines.iScience · 2020Article
- Exogenous transforming growth factor-β1 enhances smooth muscle differentiation in embryonic mouse jejunal explants.Journal of tissue engineering and regenerative medicine · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowth factors (GFs) are milk bioactive components contributing to the regulation of neonatal small intestinal maturation, and their receptors on the small intestinal epithelium play essential roles in mediating the functions of GFs. There is limited data correlating milk GFs and their receptors in the neonatal small intestine during the perinatal period.
methodsSmall intestines of C57BL/6N mouse pups were collected at regular intervals during fetal life and up to postnatal day (PD) 60. Gene expression of GF receptors was determined by real-time qPCR. Milk GF concentrations up to PD21 were analyzed by enzyme-linked immunosorbent assay.
resultsThe majority of GF receptors showed significantly greater expression in the fetus than in postnatal life, and a sharp decrease occurred from PD14 extending to PD60; solid food restriction (PD14 and PD18) did not affect this decrease. Concentrations of five detected milk GFs demonstrated that GFs and the corresponding small intestinal receptors exhibited different correlations, with only milk transforming growth factor β1 (TGF-β1) having a significant positive correlation with TGF-β receptor 1 mRNA.
conclusionGene expression of small intestinal GF receptors is likely a process of neonatal intestinal maturation that is affected concurrently by milk GFs and additional endogenous factors.
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