Observational studyPediatric research2016
Near-infrared spectroscopy for detection of a significant patent ductus arteriosus.
Observational study in Pediatric research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of NIRS to Detect Acute Kidney Injury in Preterm Infants
Protecting Brains and Saving Futures - the PBSF Protocol: a Prospective Multicenter and Observational Study on the Use of Telemedicine for Neurocritical Care in High-risk Newborns in Brazil.
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Regional oxygen saturation as a non-invasive indicator for neonatal PDA: a systematic review and meta-analysis.BMC pediatrics · 2026Pooled it
- Noninvasive diffuse optical monitoring of cerebral blood flow and oxygenation responses to intermittent hypoxia in neonatal rats.Journal of biomedical optics · 2026Article
- Autonomic Function and Cerebral Autoregulation in Children Receiving Extracorporeal Life Support.Children (Basel, Switzerland) · 2026Article
- Stealing nephrons-a review on how patent ductus arteriosus physiology impacts neonatal kidney health.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Cerebral and intestinal Doppler patterns according to patent ductus arteriosus shunt characteristics in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Comparison of Near-Infrared Spectroscopy and Traditional Parameters for Monitoring Neonates with Aortic Coarctation.Pediatric cardiology · 2026Article
- Liver Regional Oxygen Saturation in Preterm Infants with Patent Ductus Arteriosus Status.Biomedicines · 2026Article
- Assessment of vital organ oxygenation by near-infrared spectroscopy in pharmacologic closure therapy for patent ductus arteriosus in preterm neonates.Revista da Associacao Medica Brasileira (1992) · 2026Observational
- A narrative review of the clinical applications of renal NIRS and integration with cerebral NIRS in the NICU.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- The use of near-infrared spectroscopy to measure kidney oxygenation in the neonatal intensive care unit.Pediatric nephrology (Berlin, Germany) · 2025Review
- Improvement of pulmonary edema and respiratory status after transcatheter PDA closure in the smallest and most premature infants.Frontiers in pediatrics · 2025Article
- Impact of catheterized ductal closure on renal and cerebral oximetry in premature neonates.European journal of pediatrics · 2024Observational
- Nutritional Strategies for Preterm Neonates and Preterm Neonates Undergoing Surgery: New Insights for Practice and Wrong Beliefs to Uproot.Nutrients · 2024Review
- Comparison of the Effects of Anaesthesia Methods Used in Caesarean Delivery on Neonatal Cerebral and Renal Oxygenation: A Randomised Controlled Trial.Journal of clinical medicine · 2024Article
- Should we "eliminate" PDA shunt in preterm infants? A narrative review.Frontiers in pediatrics · 2024Review
- The impact of a PDA on tissue oxygenation and haemodynamics following a blood transfusion in preterm infants.Pediatric research · 2023Observational
- Newer indications for neuromonitoring in critically ill neonates.Frontiers in pediatrics · 2023Article
- Novel approaches to capturing and using continuous cardiorespiratory physiological data in hospitalized children.Pediatric research · 2023Review
- Editorial: Advances in the use of neuromonitoring in newborns.Frontiers in pediatrics · 2023Article
- Patent ductus arteriosus and spontaneous intestinal perforation in a cohort of preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNear-infrared spectroscopy (NIRS) may assist with characterization of a hemodynamically significant patent ductus arteriosus (hsPDA) by measuring cerebral and renal saturation (Csat and Rsat) levels. We hypothesized that Csat and Rsat in preterm infants with an hsPDA would be decreased compared to those with no PDA or nonsignificant PDA.
methodsThis non a-priori designed study retrospectively investigated clinical and ECHO characteristics of preterm infants <29 wk gestation who underwent routine NIRS monitoring. Logistic regression assessed association between NIRS measures and an hsPDA by ECHO.
resultsOf 47 infants, 21 had a confirmed hsPDA by ECHO, 14 had a nonsignificant PDA, and 12 had no ECHO performed due to low clinical suspicion for PDA. Logistic regression adjusted for gestational age found that lower Rsat was associated with an hsPDA by ECHO (OR 0.9, 95% CI 0.83-0.98, P = 0.01). Using ROC curves, Rsat < 66% identified an hsPDA with a sensitivity of 81% and specificity of 77%, while Csat was not significant.
conclusionLow Rsat < 66% was associated with the presence of an hsPDA in the preterm infant. Csat may be preserved if cerebral autoregulation is largely intact. Bedside NIRS monitoring may reasonably increase suspicion for a significant PDA in the preterm infant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.