ArticlePloS one2016
The Influence of Gestational Diabetes on Neurodevelopment of Children in the First Two Years of Life: A Prospective Study.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Gestational diabetes mellitus and adverse pregnancy outcomes: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2022 · on this mapPooled it
- Gestational diabetes detection thresholds and infant growth, nutrition, and neurodevelopment at 12-18 months: a prospective cohort study within a randomized trial.Journal of perinatology : official journal of the California Perinatal Association · 2025Trial
- Maternal dysglycaemia, changes in the infant's epigenome modified with a diet and physical activity intervention in pregnancy: Secondary analysis of a randomised control trial.PLoS medicine · 2020Trial
- Umbilical cord blood biomarkers of neuronal injury in sleep-disordered breathing during pregnancy.Scientific reports · 2026Article
- Neurodevelopmental outcomes of children born to diabetic mothers in the Qatari population: a retrospective study.BMJ paediatrics open · 2026Article
- Prenatal Glucose Intolerance and Child Neurodevelopmental Disorders.JAMA network open · 2025Article
- Maternal serum and placental metabolomes in association with prenatal exposure to per- and polyfluoroalkyl substances and their relevance to child neurodevelopment in an ASD-enriched cohort.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Assessment of neonatologists' competency in managing gestational diabetes complications: a cross-sectional analysis from China.Frontiers in endocrinology · 2025Article
- Maternal Gestational Diabetes Mellitus (GDM) Moderates the Association Between Birth Weight and EEG Power in Healthy Term-Age Newborns.Developmental psychobiology · 2025Article
- Circular RNA hsa_circ_0002268 (International journal of molecular sciences · 2024Article
- Allostatic load in children: The cost of empathic concern.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Maternal Diabetes Deregulates the Expression of Mecp2 via miR-26b-5p in Mouse Embryonic Neural Stem Cells.Cells · 2023Article
- An update on the long-term outcomes of prenatal dexamethasone treatment in congenital adrenal hyperplasia.Endocrine connections · 2023Review
- Maternal weight, gut microbiota, and the association with early childhood behavior: the PREOBE follow-up study.Child and adolescent psychiatry and mental health · 2023Article
- The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence.Frontiers in endocrinology · 2023Review
- Neurodevelopmental delay up to the age of 4 years in infants born to women with gestational diabetes mellitus: The Japan Environment and Children's Study.Journal of diabetes investigation · 2022Article
- Maternal Cardiovascular Health in Early Pregnancy and Childhood Brain Structure.Journal of the American Heart Association · 2022Article
- A national prevalence and profile of single and multiple developmental delays among children aged from 1 year up to 12 years: an Egyptian community-based study.Child and adolescent psychiatry and mental health · 2022Article
- THYROID DYSFUNCTION IN PREGNANCY: COMPARISON OF OUTCOMES IN INFANTS.Acta clinica Croatica · 2022Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 4 countries.
Funding
Abstract
objectiveAnalyze the relation of gestational diabetes and maternal blood glucose levels to early cognitive functions in the first two years of life.
methodsIn a prospective Singaporean birth cohort study, pregnant women were screened for gestational diabetes at 26-28 weeks gestation using a 75-g oral glucose tolerance test. Four hundred and seventy three children (n = 74 and n = 399 born to mothers with and without gestational diabetes respectively) underwent neurocognitive assessments at 6, 18, and/or 24 month, including electrophysiology during an attentional task and behavioral measures of attention, memory and cognition.
resultsGestational diabetes is related to left hemisphere EPmax amplitude differences (oddball versus standard) at both six (P = 0.039) and eighteen months (P = 0.039), with mean amplitudes suggesting offspring of mothers with gestational diabetes exhibit greater neuronal activity to standard stimuli and less to oddball stimuli. Associations between 2-hour maternal glucose levels and the difference in EPmax amplitude were marginal at 6 months [adjusted β = -0.19 (95% CI: -0.42 to +0.04) μV, P = 0.100] and significant at 18 months [adjusted β = -0.27 (95% CI: -0.49 to -0.06) μV, P = 0.014], and the EPmax amplitude difference (oddball-standard) associated with the Bayley Scales of Infant and toddler Development-III cognitive score at 24 months [β = 0.598 (95% CI: 0.158 to 1.038), P = 0.008].
conclusionGestational diabetes and maternal blood glucose levels are associated with offspring neuronal activity during an attentional task at both six and eighteen months. Such electrophysiological differences are likely functionally important, having been previously linked to attention problems later in life.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.