Evidence map›Paper›PMID 27603001›Full record

ArticleJournal of alternative and complementary medicine (New York, N.Y.)2016

Qualitative Assessment of Patients Receiving Prolotherapy for Knee Osteoarthritis in a Multimethod Study.

David Rabago, Laura van Leuven, Lane Benes, Luke Fortney, Andrew Slattengren, Jessica Grettie, Marlon Mundt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of alternative and complementary medicine (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 1 country.

David Rabago1 The Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health , Madison, WI.
Laura van Leuven1 The Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health , Madison, WI.
Lane Benes2 Department of Medicine, University of Chicago , Chicago, IL.
Luke Fortney3 McKee Clinic Family Medicine , Meriter Unity Point Health, Madison, WI.
Andrew Slattengren4 Department of Family Medicine and Community Health, Broadway Family Medicine Clinic, University of Minnesota Medical School , Minneapolis, MN.
Jessica Grettie5 Wisconsin Center for Education Research, University of Wisconsin , Madison, WI.
Marlon Mundt1 The Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health , Madison, WI.
University of Wisconsin–Madison · USUnityPoint Health Meriter · USUniversity of Chicago · USUniversity of Minnesota Medical Center · USUniversity of Wisconsin Health · USWisconsin Division of Public Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRandomized and open-label studies assessing prolotherapy for knee osteoarthritis have found quantitative improvement on the validated Western Ontario McMaster University Osteoarthritis Index (WOMAC) compared with baseline status and control therapies. This study assessed the qualitative response of participants receiving prolotherapy, an injection-based complementary treatment for symptomatic knee osteoarthritis (OA).

designQualitative study using semi-structured in-depth interviews at 52 weeks after enrollment; transcribed responses were discussed by coauthors to identify themes; disagreement was resolved by consensus.

settingOutpatient.

participantsTwenty-two participants treated with prolotherapy for symptomatic knee OA who were exited from three randomized and open-label studies.

interventionsIntra- and extra-articular hypertonic dextrose injection (prolotherapy).

main outcome measuresPatient narrative and composite WOMAC questionnaire (0-100 points) scores.

resultsParticipants had baseline demographic and knee OA severity similar to those of participants in three prior intervention trials, as well as similar robust follow-up WOMAC score change (19.9 ± 12.6 points), suggesting a representative subsample. Seven themes were identified from participant narratives: (1) improvement in knee-specific quality of life (n = 18), (2) safety and comfort, (3) pretreatment counseling enhanced treatment adherence and optimism, (4) overall positive experience with prolotherapy, (5) limited response to prolotherapy (n = 4), (6) consistency with anecdotal clinical prolotherapy experience; and (7) functional improvement without pain reduction.

conclusionsMost participants reported substantially improved knee-specific effects, resulting in improved quality of life and activities of daily living; four participants reported minimal or no effect. Clear, complete description of procedural rationale may enhance optimism about and adherence to treatment appointments.

Indexed as

Patient SatisfactionCohort StudiesComplementary TherapiesFemaleGlucoseHumansInterviews as TopicMaleMiddle AgedOsteoarthritis, KneeRandomized Controlled Trials as TopicRegenerative MedicineGlucosedextrose injectionknee osteoarthritisprolotherapyqualitative studyregenerative medicine

Identifiers

PMID27603001
PMCPMC5175418
OpenAlexW2519885037

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.