ArticleOncotarget2016
Single-cell analyses of transcriptional heterogeneity in squamous cell carcinoma of urinary bladder.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- The Emerging Role of CACNA1E in Cancer: Molecular Mechanisms and Therapeutic Implications.Journal of Cancer · 2026Review
- Single-cell RNA sequencing analysis identifies acute changes in the tumor microenvironment induced by interferon α gene therapy in a murine bladder cancer model.Frontiers in immunology · 2024Article
- Clinical implications of single cell sequencing for bladder cancer.Oncology research · 2024Review
- Characterization of gene cluster heterogeneity in single-cell transcriptomic data within and across cancer types.Biology open · 2022Article
- Single-cell sequencing technologies in bladder cancer research: Applications and challenges.Frontiers in genetics · 2022Review
- Exploration of potential therapeutic targets for stroke based on the GEO database.Annals of translational medicine · 2021Article
- Comprehensive analysis of metastatic gastric cancer tumour cells using single-cell RNA-seq.Scientific reports · 2021Article
- Identification and Validation of the Prognostic Stemness Biomarkers in Bladder Cancer Bone Metastasis.Frontiers in oncology · 2021Article
- Role of Epstein-Barr Virus and Human Papillomavirus Coinfection in Cervical Intraepithelial Neoplasia in Chinese Women Living With HIV.Frontiers in cellular and infection microbiology · 2021Article
- Identification and Analysis of An Epigenetically Regulated Five-lncRNA Signature Associated With Outcome and Chemotherapy Response in Ovarian Cancer.Frontiers in cell and developmental biology · 2021Article
- Tumor heterogeneity in muscle-invasive bladder cancer.Translational andrology and urology · 2020Review
- Traditional Classification and Novel Subtyping Systems for Bladder Cancer.Frontiers in oncology · 2020Review
- Emerging roles for multifunctional ion channel auxiliary subunits in cancer.Cell calcium · 2019Review
- Identification of biomarkers associated with progression and prognosis in bladder cancer via co-expression analysis.Cancer biomarkers : section A of Disease markers · 2019Article
- Bladder cancer stage-associated hub genes revealed by WGCNA co-expression network analysis.Hereditas · 2019Article
- Single-cell analysis of tumors: Creating new value for molecular biomarker discovery of cancer stem cells and tumor-infiltrating immune cells.World journal of stem cells · 2018Review
- Emerging Biomarkers in Bladder Cancer Identified by Network Analysis of Transcriptomic Data.Frontiers in oncology · 2018Review
- Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis.Clinical and translational medicine · 2017Review
- Mechanisms and clinical implications of tumor heterogeneity and convergence on recurrent phenotypes.Journal of molecular medicine (Berlin, Germany) · 2017Review
- Mining Cancer Transcriptomes: Bioinformatic Tools and the Remaining Challenges.Molecular diagnosis & therapy · 2017Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell-to-cell expression heterogeneity within a single tumor is a common phenotype among various cancer types including squamous cell carcinoma. To further study the fundamentals and importance of heterogeneity of cell functions and its potential mechanisms, we performed single-cell RNA-seq (scRNA-seq) on human squamous cell carcinoma of the bladder (SCCB) and its corresponding physiologically normal epithelia. Extensive differentially expressed genes were uncovered by comparing cancer and normal single cells, which were preferentially enriched in cancer-correlated pathways, such as p53 signaling and bladder cancer pathway. Furthermore, the most diversely expressed genes were particularly enriched in MAPK signaling pathway, such as CACNG4, CACNA1E and CACNA1H, which involve in cancer evolution and heterogeneity formation. Co-expression network and hub-gene analyses revealed several remarkable "hub genes" of each regulatory module. Some of them are cancer related, such as POU2F3, NKD1 and CYP2C8, while LINC00189, GCC2 and OR9Q1 genes are rarely reported in human diseases. The genes within an interesting module are highly correlated with others, which could be treated as potential targets for SCCB patients. Our findings have fundamental implications for SCCB biology and therapeutic strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.