ArticleBiophysical journal2016
A Flux Balance of Glucose Metabolism Clarifies the Requirements of the Warburg Effect.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- A bioenergetic understanding of "aerobic glycolysis".Communications biology · 2026Review
- Surface Complex V couples proton gradient across the plasma membrane to ATP production in cancer.Research square · 2026Article
- Surface Complex V couples proton gradient across the plasma membrane to ATP production in cancer.bioRxiv : the preprint server for biology · 2026Article
- A Far-Red FRET biosensor for AMPK enables multiplexed imaging of single-cell bioenergetic homeostasis.bioRxiv : the preprint server for biology · 2026Article
- Emergence of Sprouty role from the signaling interplay of DUSP1 and DUSP4 interactions in NSCLC pathogenesis.NPJ systems biology and applications · 2026Article
- The return of metabolism: biochemistry and physiology of glycolysis.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Transcriptomic Insights into the Degradation Mechanisms ofMicroorganisms · 2025Article
- The Warburg Effect is the result of faster ATP production by glycolysis than respiration.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Review
- Including glutamine in a resource allocation model of energy metabolism in cancer and yeast cells.NPJ systems biology and applications · 2024Article
- The Warburg effect: a signature of mitochondrial overload.Trends in cell biology · 2023Review
- Article
- Natural compounds as lactate dehydrogenase inhibitors: potential therapeutics for lactate dehydrogenase inhibitors-related diseases.Frontiers in pharmacology · 2023Review
- Hybrid computational models of multicellular tumour growth considering glucose metabolism.Computational and structural biotechnology journal · 2023Review
- Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.Nature communications · 2022Article
- Deciphering the mechanism by which the yeast Phaffia rhodozyma responds adaptively to environmental, nutritional, and genetic cues.Journal of industrial microbiology & biotechnology · 2021Review
- Model systems in SDHx-related pheochromocytoma/paraganglioma.Cancer metastasis reviews · 2021Review
- Microeconomics of Metabolism: The Warburg Effect as Giffen Behaviour.Bulletin of mathematical biology · 2021Article
- Potential of electron transfer and its application in dictating routes of biochemical processes associated with metabolic reprogramming.Frontiers of medicine · 2021Review
- Metabolic landscapes in sarcomas.Journal of hematology & oncology · 2021Review
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Authors and funding
4 authors.
Funding
Abstract
The Warburg effect, or aerobic glycolysis, is marked by the increased metabolism of glucose to lactate in the presence of oxygen. Despite its widespread prevalence in physiology and cancer biology, the causes and consequences remain incompletely understood. Here, we show that a simple balance of interacting fluxes in glycolysis creates constraints that impose the necessary conditions for glycolytic flux to generate lactate as opposed to entering into the mitochondria. These conditions are determined by cellular redox and energy demands. By analyzing the constraints and sampling the feasible region of the model, we further study how cell proliferation rate and mitochondria-associated NADH oxidizing and ATP producing fluxes are interlinked. Together this analysis illustrates the simplicity of the origins of the Warburg effect by identifying the flux distributions that are necessary for its instantiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.