ArticleBiophysical journal2016
Fibrin Networks Support Recurring Mechanical Loads by Adapting their Structure across Multiple Scales.
Article in Biophysical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Fibrin as a Versatile Fibrous Biopolymer.Sub-cellular biochemistry · 2026Review
- Loading causes molecular damage in fibrin fibers.Soft matter · 2025Article
- Fatty acid albumin conjugates mechanically weaken and disrupt degradation of fibrin networks.Acta biomaterialia · 2025Article
- Laser speckle rheological microscopy reveals wideband viscoelastic spectra of biological tissues.Science advances · 2024Article
- Feeling a nanoworld with optical tweezers: Hands on training at IUPAB 2024.Biophysics and physicobiology · 2024Article
- Dynamic remodeling of fiber networks with stiff inclusions under compressive loading.Acta biomaterialia · 2023Article
- Multiscale architecture: Mechanics of composite cytoskeletal networks.Biophysics reviews · 2022Review
- Structural control of fibrin bioactivity by mechanical deformation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Cell-matrix reciprocity in 3D culture models with nonlinear elasticity.Bioactive materials · 2022Review
- The mechanics of fibrillar collagen extracellular matrix.Cell reports. Physical science · 2021Article
- Blood Clot Phenotyping by Rheometry: Platelets and Fibrinogen Chemistry Affect Stress-Softening and -Stiffening at Large Oscillation Amplitude.Molecules (Basel, Switzerland) · 2020Article
- Engineered Biomaterial Platforms to Study Fibrosis.Advanced healthcare materials · 2020Review
- Mechanochemical Adhesion and Plasticity in Multifiber Hydrogel Networks.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Optical Tweezers Approaches for Probing Multiscale Protein Mechanics and Assembly.Frontiers in molecular biosciences · 2020Review
- Damped White Noise Diffusion with Memory for Diffusing Microprobes in Ageing Fibrin Gels.Biophysical journal · 2019Article
- Contribution of nascent cohesive fiber-fiber interactions to the non-linear elasticity of fibrin networks under tensile load.Acta biomaterialia · 2019Article
- Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces.Biophysical journal · 2018Article
- Review
- Buffers Strongly Modulate Fibrin Self-Assembly into Fibrous Networks.Langmuir : the ACS journal of surfaces and colloids · 2017Article
- The Inelastic Hierarchy: Multiscale Biomechanics of Weak Bonds.Biophysical journal · 2016Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissues and cells sustain recurring mechanical loads that span a wide range of loading amplitudes and timescales as a consequence of exposure to blood flow, muscle activity, and external impact. Both tissues and cells derive their mechanical strength from fibrous protein scaffolds, which typically have a complex hierarchical structure. In this study, we focus on a prototypical hierarchical biomaterial, fibrin, which is one of the most resilient naturally occurring biopolymers and forms the structural scaffold of blood clots. We show how fibrous networks composed of fibrin utilize irreversible changes in their hierarchical structure at different scales to maintain reversible stress stiffening up to large strains. To trace the origin of this paradoxical resilience, we systematically tuned the microstructural parameters of fibrin and used a combination of optical tweezers and fluorescence microscopy to measure the interactions of single fibrin fibers for the first time, to our knowledge. We demonstrate that fibrin networks adapt to moderate strains by remodeling at the network scale through the spontaneous formation of new bonds between fibers, whereas they adapt to high strains by plastic remodeling of the fibers themselves. This multiscale adaptation mechanism endows fibrin gels with the remarkable ability to sustain recurring loads due to shear flows and wound stretching. Our findings therefore reveal a microscopic mechanism by which tissues and cells can balance elastic nonlinearity and plasticity, and thus can provide microstructural insights into cell-driven remodeling of tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.