Evidence map›Paper›PMID 27602518›Full record

ArticleNature2016

m(6)A RNA methylation promotes XIST-mediated transcriptional repression.

Deepak P Patil, Chun-Kan Chen, Brian F Pickering, Amy Chow, Constanza Jackson, Mitchell Guttman, Samie R Jaffrey

Abstract read
In one paragraph

Article in Nature, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,169 papers.

0numbers the graph read from it
0cells of the map it votes in
1,169citing papers in PubMed
52.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,169 citing papers in PubMed, 1,762 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. RNA mActa pharmacologica Sinica · 2026
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. mNature reviews. Neuroscience · 2026
    Review
  19. The mMolecular psychiatry · 2026
    Article
  20. Emerging roles of mJournal of assisted reproduction and genetics · 2026
    Review

1,109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Deepak P PatilDepartment of Pharmacology, Weill-Cornell Medical College, Cornell University, New York, New York 10065, USA.
Chun-Kan ChenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Brian F PickeringDepartment of Pharmacology, Weill-Cornell Medical College, Cornell University, New York, New York 10065, USA.
Amy ChowDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Constanza JacksonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Mitchell GuttmanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Samie R JaffreyDepartment of Pharmacology, Weill-Cornell Medical College, Cornell University, New York, New York 10065, USA.
California Institute of Technology · USCornell University · US

Funding

PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRYT32GM007616 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 1985 to 2019
$22.9M
CANCER PHARMACOLOGYT32CA062948 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LORRAINE J GUDAS · 1994 to 2026
$12.1M
Mechanisms of epitranscriptomic regulation in cancerR01CA186702 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI SAMIE R JAFFREY, Michael Kharas · 2014 to 2026
$8.0M
Deciphering the mechanism of large ncRNA mediated regulation of cell stateDP5OD012190 · OD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GUTTMAN, MITCHELL · 2012 to 2016
$2.4M
NCI NIH HHS R01 CA186702NCI NIH HHS T32 CA062948NIGMS NIH HHS T32 GM007616NIH HHS DP5 OD012190
6 · The paper itself

Abstract

The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly methylated with at least 78 N

Indexed as

Gene SilencingTranscription, GeneticAdenosineAnimalsCell Cycle ProteinsCell LineEmbryonic Stem CellsFemaleHEK293 CellsHumansMaleMethylationMethyltransferasesMiceNerve Tissue ProteinsNuclear ProteinsAdenosineCell Cycle ProteinsMethyltransferasesMETTL3 protein, humanNerve Tissue ProteinsN-methyladenosineNuclear ProteinsRBM15 protein, humanRNA-Binding ProteinsRNA, Long NoncodingRNA Splicing FactorsWTAP protein, humanXIST non-coding RNAYTHDC1 protein, human

Identifiers

PMID27602518
PMCPMC5509218
OpenAlexW2509465044

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.