ArticlePeerJ2016
Isolation of an antimicrobial compound produced by bacteria associated with reef-building corals.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
62 citing papers in PubMed, 165 citations in OpenAlex.
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- The Coral Host Microbiome Modulates the Virulence of the Bacterial Pathogen Vibrio coralliilyticus.Environmental microbiology · 2026Article
- Impacts of Nearby Algae on Recruitment Success and Early Microbiome Development of the Coral Acropora cytherea.Environmental microbiology · 2026Article
- Heatwave-driven persistent microbes threaten the resilience of Mediterranean coral holobionts.Environmental microbiome · 2025Article
- Genomic potential of crustose coralline algae-associated bacteria for the biosynthesis of novel antimicrobials.Microbial genomics · 2025Article
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- Mini review: antimicrobial compounds produced by bacteria associated with marine invertebrates.Folia microbiologica · 2025Review
- Discovery of Peptidic Siderophore Degradation by Screening Natural Product Profiles in Marine-Derived Bacterial Mono- and Cocultures.Biochemistry · 2025Article
- Halobacteriovorax halts disease progression in endangered Caribbean corals.The ISME journal · 2025Article
- Draft genome of aMicrobiology resource announcements · 2024Article
- Microbial and transcriptional response of Acropora valida and Turbinaria peltata to Vibrio coralliilyticus challenge: insights into corals disease resistance.BMC microbiology · 2024Article
- The coral microbiome in sickness, in health and in a changing world.Nature reviews. Microbiology · 2024Review
- Pre-Bleaching Coral Microbiome Is Enriched in Beneficial Taxa and Functions.Microorganisms · 2024Article
- Probiotics reshape the coral microbiome in situ without detectable off-target effects in the surrounding environment.Communications biology · 2024Article
- A genome-centric view of the role of the Acropora kenti microbiome in coral health and resilience.Nature communications · 2024Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial communities associated with healthy corals produce antimicrobial compounds that inhibit the colonization and growth of invasive microbes and potential pathogens. To date, however, bacteria-derived antimicrobial molecules have not been identified in reef-building corals. Here, we report the isolation of an antimicrobial compound produced by Pseudovibrio sp. P12, a common and abundant coral-associated bacterium. This strain was capable of metabolizing dimethylsulfoniopropionate (DMSP), a sulfur molecule produced in high concentrations by reef-building corals and playing a role in structuring their bacterial communities. Bioassay-guided fractionation coupled with nuclear magnetic resonance (NMR) and mass spectrometry (MS), identified the antimicrobial as tropodithietic acid (TDA), a sulfur-containing compound likely derived from DMSP catabolism. TDA was produced in large quantities by Pseudovibrio sp., and prevented the growth of two previously identified coral pathogens, Vibrio coralliilyticus and V. owensii, at very low concentrations (0.5 μg/mL) in agar diffusion assays. Genome sequencing of Pseudovibrio sp. P12 identified gene homologs likely involved in the metabolism of DMSP and production of TDA. These results provide additional evidence for the integral role of DMSP in structuring coral-associated bacterial communities and underline the potential of these DMSP-metabolizing microbes to contribute to coral disease prevention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.