ReviewWorld journal of gastrointestinal pharmacology and therapeutics2016
Intestinal neuronal dysplasia type B: A still little known diagnosis for organic causes of intestinal chronic constipation.
Review in World journal of gastrointestinal pharmacology and therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Clinical characteristics, pathological comorbidities, BMI-for-age Z-score, and machine learning-based exploration of postoperative enterocolitis in iIntestinal neuronal dysplasia: a 20-year retrospective study.Pediatric surgery international · 2026Article
- Intestinal Neuronal Dysplasia Type B as Rare Organic Cause of Refractory Constipation in Adults: A Case Report and Literature Review.Clinics and practice · 2026Article
- Article
- Article
- Association between Clinical and Histopathological Findings in Intestinal Neuronal Dysplasia Type B: An Advance towards Its Definition as a Disease.Life (Basel, Switzerland) · 2023Article
- The mechanism of intestinal flora dysregulation mediated by intestinal bacterial biofilm to induce constipation.Bioengineered · 2021Article
- Challenges in the diagnosis of intestinal neuronal dysplasia type B: A look beyond the number of ganglion cells.World journal of gastroenterology · 2021Review
- Identification of potential molecular pathogenesis mechanisms modulated by microRNAs in patients with Intestinal Neuronal Dysplasia type B.Scientific reports · 2019Article
- Atrophic Myenteric and Submucosal Neurons Are Observed in Parkinson's Disease.Parkinson's disease · 2019Article
- Development of the Enteric Nervous System: A Genetic Guide to the Perplexed.Gastroenterology · 2018Article
- Laparoscopic-assisted endorectal pull-through for Hirschsprung's disease. A retrospective study.Saudi medical journal · 2017Article
- A critical appraisal of the morphological criteria for diagnosing intestinal neuronal dysplasia type B.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- Observational
- Pediatric enteric neuropathies: diagnosis and current management.Current opinion in pediatrics · 2017Review
- Advances in understanding functional variations in the Hirschsprung disease spectrum (variant Hirschsprung disease).Pediatric surgery international · 2017Review
- The evaluation of rectal mucosal punch biopsy in the diagnosis of Hirschsprung's disease: a 30-year experience of 954 patients.Pediatric surgery international · 2017Article
- A case of single incision laparoscopic total colectomy for intestinal neuronal dysplasia type B.International journal of surgery case reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intestinal neuronal dysplasia type B (IND-B) is a controversial entity among the gastrointestinal neuromuscular disorders. It may occur alone or associated with other neuropathies, such as Hirschsprung's disease (HD). Chronic constipation is the most common clinical manifestation of patients. IND-B primarily affects young children and mimics HD, but has its own histopathologic features characterized mainly by hyperplasia of the submucosal nerve plexus. Thus, IND-B should be included in the differential diagnoses of organic causes of constipation. In recent years, an increasing number of cases of IND-B in adults have also been described, some presenting severe constipation since childhood and others with the onset of symptoms at adulthood. Despite the intense scientific research in the last decades, there are still knowledge gaps regarding definition, pathogenesis, diagnostic criteria and therapeutic possibilities for IND-B. However, in medical practice, we continue to encounter patients with severe constipation or intestinal obstruction who undergo to diagnostic investigation for HD and their rectal biopsies present hyperganglionosis in the submucosal nerve plexus and other features, consistent with the diagnosis of IND-B. This review critically discusses aspects related to the disease definitions, pathophysiology and genetics, epidemiology distribution, clinical presentation, diagnostic criteria and therapeutic possibilities of this still little-known organic cause of intestinal chronic constipation.
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