ReviewWorld journal of gastrointestinal pharmacology and therapeutics2016
Management of pain in chronic pancreatitis with emphasis on exogenous pancreatic enzymes.
Review in World journal of gastrointestinal pharmacology and therapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 30 citations in OpenAlex.
- Pain in chronic pancreatitis: What can we do today?World journal of methodology · 2024Review
- Imaging of inflammatory disease of the pancreas.The British journal of radiology · 2021Review
- ACVIM consensus statement on pancreatitis in cats.Journal of veterinary internal medicine · 2021Article
- The influence of erythropoietin on apoptosis and fibrosis in the early phase of chronic pancreatitis in rats.Archives of medical science : AMS · 2021Article
- Piperine ameliorates the severity of fibrosis via inhibition of TGF‑β/SMAD signaling in a mouse model of chronic pancreatitis.Molecular medicine reports · 2019Article
- Anterograde Endoscopic Ultrasound-Guided Pancreatic Duct Drainage: A Technical Review.Digestive diseases and sciences · 2019Review
- Rational Use of Pancreatic Enzymes for Pancreatic Insufficiency and Pancreatic Pain.Advances in experimental medicine and biology · 2019Review
- SCIENTISTS and SCIENCE ADVOCATES: Professor David Y. Graham: A Brilliant Scientist and a Compassionate MentorIranian biomedical journal · 2018Article
- Observational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
One of the most challenging issues arising in patients with chronic pancreatitis is the management of abdominal pain. Many competing theories exist to explain pancreatic pain including ductal hypertension from strictures and stones, increased interstitial pressure from glandular fibrosis, pancreatic neuritis, and ischemia. This clinical problem is superimposed on a background of reduced enzyme secretion and altered feedback mechanisms. Throughout history, investigators have used these theories to devise methods to combat chronic pancreatic pain including: Lifestyle measures, antioxidants, analgesics, administration of exogenous pancreatic enzymes, endoscopic drainage procedures, and surgical drainage and resection procedures. While the value of each modality has been debated over the years, pancreatic enzyme therapy remains a viable option. Enzyme therapy restores active enzymes to the small bowel and targets the altered feedback mechanism that lead to increased pancreatic ductal and tissue pressures, ischemia, and pain. Here, we review the mechanisms and treatments for chronic pancreatic pain with a specific focus on pancreatic enzyme replacement therapy. We also discuss different approaches to overcoming a lack of clinical response update ideas for studies needed to improve the clinical use of pancreatic enzymes to ameliorate pancreatic pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.