Evidence map›Paper›PMID 27602159›Full record

ArticleOncology letters2016

Epigenetic regulation of miRNA-124 and multiple downstream targets is associated with treatment response in myeloid malignancies.

Hongbin Liu, Phillip Pattie, Sahan Chandrasekara, Andrew Spencer, Anthony E Dear

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hongbin LiuAustralian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia; Translational Research Division, Eastern Clinical Research Unit, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia.
Phillip PattieAustralian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia; Translational Research Division, Eastern Clinical Research Unit, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia.
Sahan ChandrasekaraDepartment of Medicine, Eastern Health Clinical School, Monash University, Melbourne, Victoria 3128, Australia.
Andrew SpencerAustralian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia.
Anthony E DearAustralian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia; Translational Research Division, Eastern Clinical Research Unit, Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria 3004, Australia; Department of Medicine, Eastern Health Clinical School, Monash University, Melbourne, Victoria 3128, Australia.
Monash University · AUEastern Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epigenetic regulation of microRNA (miRNA) expression has recently been implicated in the pathogenesis of myelodysplastic syndrome (MDS). Particular interest has focused on miRNA-124 expression, which is inhibited in MDS and has recently been demonstrated to be upregulated in response to epigenetic treatment (EGT). Previous studies have determined the

Indexed as

biomarkerepigeneticmiRNAmyelodysplasiamyeloid leukemia

Identifiers

PMID27602159
PMCPMC4998575
OpenAlexW2487746532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.