Evidence map›Paper›PMID 27602140›Full record

ArticleOncology letters2016

Expression of microRNA-30a-5p in drug-resistant and drug-sensitive ovarian cancer cell lines.

Jin Liu, Xiaohua Wu, Hongmei Liu, Yijuan Liang, Xinping Gao, Zhihui Cai, Weiming Wang, Hui Zhang

Open access · diamondAbstract read
In one paragraph

Article in Oncology letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jin LiuDepartment of Gynecology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China; Department of Gynecology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.
Xiaohua WuDepartment of Gynecology, Hebei Medical University, Shijiazhuang, Hebei 050017, P.R. China; Department of Gynecology, Bethune International Peace Hospital, Shijiazhuang, Hebei 050000, P.R. China.
Hongmei LiuDepartment of Molecular Medicine, Hebei University, Baoding, Hebei 071000, P.R. China.
Yijuan LiangDepartment of Gynecology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.
Xinping GaoDepartment of Gynecology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.
Zhihui CaiDepartment of Gynecology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.
Weiming WangDepartment of Gynecology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.
Hui ZhangDepartment of Gynecology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China.
Affiliated Hospital of Hebei University · CNHebei Medical University · CNHebei University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to explore the expression of microRNA (miRNA or miR) in drug-resistant and drug-sensitive ovarian cancer cell lines, and to seek the potential therapeutic target of ovarian cancer drug-resistant mechanism in order to improve drug resistance by altering miRNA levels. The drug-resistant characteristics of SKOV3/DDP, SKOV3, COC1/DDP and COC1 cell lines were studied. The miRNAs that were differentially expressed between cisplatin-resistant cells and its parental cells in ovarian cancer were screened with a miRNA chip. The effect of miRNAs was detected, and their drug-resistant mechanism was investigated by transfection and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide methods. Among the expression screening of miRNAs, 41 mRNAs, including

Indexed as

drug resistancemicroRNAmicroRNA-30a-5povarian cancer

Identifiers

PMID27602140
PMCPMC4998657
OpenAlexW2474544325

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.