ArticleFrontiers in microbiology2016
Pseudomonas fluorescens Filamentous Hemagglutinin, an Iron-Regulated Protein, Is an Important Virulence Factor that Modulates Bacterial Pathogenicity.
Article in Frontiers in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
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- Haemolysins are essential to the pathogenicity of deep-seaiScience · 2024Article
- Metagenomic insights into the response of soil microbial communities to pathogenicFrontiers in plant science · 2024Article
- Condensins are essential for Pseudomonas aeruginosa corneal virulence through their control of lifestyle and virulence programs.Molecular microbiology · 2022Article
- The use of filamentous hemagglutinin adhesin to detect immune responses toFrontiers in veterinary science · 2022Article
- Analysis of the Taxonomy, Synteny, and Virulence Factors for Soft Rot PathogenFrontiers in microbiology · 2022Article
- Comparative roles of three adhesin genes (adh1-3) in insect-pathogenic lifecycle of Beauveria bassiana.Applied microbiology and biotechnology · 2021Article
- Article
- Thymol Inhibits Biofilm Formation, Eliminates Pre-Existing Biofilms, and Enhances Clearance of Methicillin-ResistantMicroorganisms · 2020Article
- Draft genome sequence of the strain 16-537536, isolated from a patient with bronchiectasis and its relationship to the Pseudomonas koreensis group of the Pseudomonas fluorescens complex.BMC research notes · 2020Article
- Biofilm and Pathogenesis-Related Proteins in the FoodborneFrontiers in microbiology · 2020Article
- Comparative bioinformatic and proteomic approaches to evaluate the outer membrane proteome of the fish pathogen Yersinia ruckeri.Journal of proteomics · 2019Article
- Taxonomic and functional heterogeneity of the gill microbiome in a symbiotic coastal mangrove lucinid species.The ISME journal · 2019Article
- Contact-dependent growth inhibition systems in Acinetobacter.Scientific reports · 2019Article
- Complete genome sequences of Aeromonas and Pseudomonas phages as a supportive tool for development of antibacterial treatment in aquaculture.Virology journal · 2019Article
- A First Study of the Virulence Potential of aFrontiers in cellular and infection microbiology · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudomonas fluorescens is a common bacterial pathogen to a wide range of aquaculture animals including various species of fish. In this study, we employed proteomic analysis and identified filamentous hemagglutinin (FHA) as an iron-responsive protein secreted by TSS, a pathogenic P. fluorescens isolate. In vitro study showed that compared to the wild type, the fha mutant TSSfha (i) exhibited a largely similar vegetative growth profile but significantly retarded in the ability of biofilm growth and producing extracellular matrix, (ii) displayed no apparent flagella and motility, (iii) was defective in the attachment to host cells and unable to form self-aggregation, (iv) displayed markedly reduced capacity of hemagglutination and surviving in host serum. In vivo infection analysis revealed that TSSfha was significantly attenuated in the ability of dissemination in fish tissues and inducing host mortality, and that antibody blocking of the natural FHA produced by the wild type TSS impaired the infectivity of the pathogen. Furthermore, when introduced into turbot as a subunit vaccine, recombinant FHA elicited a significant protection against lethal TSS challenge. Taken together, these results indicate for the first time that P. fluorescens FHA is a key virulence factor essential to multiple biological processes associated with pathogenicity.
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