ReviewNeuropsychiatric disease and treatment2016
Mood disorders in the elderly: prevalence, functional impact, and management challenges.
Review in Neuropsychiatric disease and treatment, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 124 citations in OpenAlex.
- Ocular light exposure interventions for sleep, circadian rhythms, rest-activity cycles, mood, and cognitive function in older adults: An Overview of Cochrane and non-Cochrane Systematic Reviews.The Cochrane database of systematic reviews · 2025Pooled it
- Cognition, body, and mind: A three-in-one coordinate-based fMRI meta-analysis on cognitive, physical, and meditative trainings.Human brain mapping · 2023Pooled it
- Early Symptom Trajectories as Predictors of Treatment Outcome for Citalopram Versus Placebo.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2017Trial
- Effects of intensity and modality of community-based exercise programs on mood profile and functional physical capacity in older women under socioeconomic vulnerability: A randomized trial.Women's health (London, England)Trial
- Depressive symptoms and neuroimaging markers of brain aging in an ethno-racially diverse sample: a Bayesian analysis.American journal of epidemiology · 2026Article
- Bipolar Disorder Hospitalization in Older Adults: A Nationwide Retrospective Study.International journal of geriatric psychiatry · 2026Observational
- Risk factors associated with depressive symptoms among institutionalized elderly in Lebanon.Scientific reports · 2026Article
- The relationship between Tai Chi practice, Psychological Resilience, and depression in older adults: an integrated study of mediation and network analysis.Frontiers in public health · 2026Article
- End-of-life issues in older adults: Emotional and social factors that shape end-of-life experiences.Advances in psychiatry and behavioral health · 2025Article
- Cross-sectional study of the association between nutrition and depression in older people living in nursing homes.BMC geriatrics · 2025Article
- Dietary acid load and its association with psychological disorders, sleep quality, and mood among Iranian older adults: a cross-sectional study.BMC public health · 2025Article
- Everyday functioning in treatment-resistant late-life depression: The mediating role of cognition.Journal of the International Neuropsychological Society : JINS · 2025Article
- The association between sarcopenic obesity and depression in middle-aged and elderly U.S. adults: insights from the NHANES study.Aging clinical and experimental research · 2025Article
- From Stress to Synapse: The Neuronal Atrophy Pathway to Mood Dysregulation.International journal of molecular sciences · 2025Review
- Do Health Literate Older People Have Fewer Depressive Symptoms? Evidence from the Urban Areas of Western China.Healthcare (Basel, Switzerland) · 2024Article
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- Research status and global trends of late-life depression from 2004 to 2023: bibliometric analysis.Frontiers in aging neuroscience · 2024Article
- Understanding the Factors Contributing to Suicide Among the Geriatric Population: A Narrative Review.Cureus · 2023Review
- The Current and Retrospective Cognitive Reserve (2CR) survey and its relationship with cognitive and mood measures.European journal of ageing · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the lower prevalence of severe mood disorders in the elderly as compared to younger adults, late-life depression and bipolar disorder (BD) are more strongly associated with negative outcomes related to the presence of medical comorbidities, cognitive deficits, and increased suicide risk and overall mortality. The mechanisms that contribute to these associations are probably multifactorial, involving pathological factors related directly and indirectly to the disease itself, ranging from biological to psychosocial factors. Most of the accumulated knowledge on the nature of these associations derives from naturalistic and observational studies, and controlled data are still scarce. Nonetheless, there has clearly been a recent growth of the scientific interest on late-life BD and geriatric depression. In the present study, we review the most relevant studies on prevalence, clinical presentation, and cognitive/functional impact of mood disorders in elderly. Several clinical-epidemiological studies were dedicated to the study of the prevalence of mood disorders in old age in distinct settings; however, fewer studies investigated the underlying neurobiological findings and treatment specificities in late-life depression and BD. In the present study, we further discuss the implications of these findings on the management of mood disorders in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.