ArticleThe Journal of infectious diseases2016
Intra-amniotic Ureaplasma parvum-Induced Maternal and Fetal Inflammation and Immune Responses in Rhesus Macaques.
Article in The Journal of infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 35 citations in OpenAlex.
- Ureaplasma parvum and Ureaplasma urealyticum induce distinct types of inflammation in neonates and human epithelial cell models.Pediatric research · 2026Article
- Pathogenesis of bronchopulmonary dysplasia: an immunological perspective.Frontiers in immunology · 2026Review
- Decidua macrophages display a restrained inflammatory profile during chorioamnionitis.Frontiers in immunology · 2026Article
- Intra-amniotic infection withBrain communications · 2025Article
- Detection ofFrontiers in cellular and infection microbiology · 2025Article
- Effects of Ureaplasma parvum infection in the exosome biogenesis-related proteins in ectocervical epithelial cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
- Impact of bisphenol A on cell viability and inflammatory cytokine production in human cervical epithelial cells.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- Ureaplasma-Driven Neonatal Neuroinflammation: Novel Insights from an Ovine Model.Cellular and molecular neurobiology · 2023Article
- A single-cell atlas of murine reproductive tissues during preterm labor.Cell reports · 2023Article
- Insights into the Black Box of Intra-Amniotic Infection and Its Impact on the Premature Lung: From Clinical and Preclinical Perspectives.International journal of molecular sciences · 2022Review
- Review
- Understanding Host-Pathogen Interactions in Acute Chorioamnionitis Through the Use of Animal Models.Frontiers in cellular and infection microbiology · 2021Review
- RNA Sequencing Reveals Diverse Functions of Amniotic Fluid Neutrophils and Monocytes/Macrophages in Intra-Amniotic Infection.Journal of innate immunity · 2021Article
- The alarmin interleukin-1α causes preterm birth through the NLRP3 inflammasome.Molecular human reproduction · 2020Article
- Intra-Amniotic Infection withmBio · 2020Article
- Fetal and amniotic fluid iron homeostasis in healthy and complicated murine, macaque, and human pregnancy.JCI insight · 2020Article
- Pulmonary Consequences of Prenatal Inflammatory Exposures: Clinical Perspective and Review of Basic Immunological Mechanisms.Frontiers in immunology · 2020Review
- Immunobiology of Acute Chorioamnionitis.Frontiers in immunology · 2020Review
- GrpE Immunization Protects AgainstFrontiers in immunology · 2020Article
- Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
Abstract
backgroundAlthough Ureaplasma species are the most common organisms associated with prematurity, their effects on the maternal and fetal immune system remain poorly characterized.
methodsRhesus macaque dams at approximately 80% gestation were injected intra-amniotically with 10
resultsAlthough U. parvum grew well in amniotic fluid, there was minimal chorioamnionitis. U. parvum colonized the fetal lung, but fetal systemic microbial invasion was limited. Fetal lung inflammation was mild, with elevations in CXCL8, tumor necrosis factor (TNF) α, and CCL2 levels in alveolar washes at day 7. Inflammation was not detected in the fetal brain. Significantly, U. parvum decreased regulatory T cells (Tregs) and activated interferon γ production in these Tregs in the fetus. It was detected in uterine tissue by day 7 and induced mild inflammation and increased expression of connexin 43, a gap junction protein involved with labor.
conclusionsU. parvum colonized the amniotic fluid and caused uterine inflammation, but without overt chorioamnionitis. It caused mild fetal lung inflammation but had a more profound effect on the fetal immune system, decreasing Tregs and polarizing them toward a T-helper 1 phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.