ArticleMolecular biology and evolution2016
Genomic Imprinting in the Endosperm Is Systematically Perturbed in Abortive Hybrid Tomato Seeds.
Article in Molecular biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 74 citations in OpenAlex.
- CrAGL62 and potential paternally expressed gene CrbZIP contribute to paternal-excess postzygotic barriers in citrus.The New phytologist · 2026Article
- Introgression and parental conflict shape repeated occurrences of postzygotic isolation in Mimulus.Current biology : CB · 2026Article
- Limited directional selection but coevolutionary signals among imprinted genes inbioRxiv : the preprint server for biology · 2026Article
- Genomic imprinting in an early-diverging angiosperm reveals an ancient mechanism for seed initiation in flowering plants.The New phytologist · 2026Article
- Bioinformatics insights into plant genomic imprinting: approaches, challenges, and future perspectives.Briefings in functional genomics · 2026Review
- Imprinting and DNA Methylation in Water Lily Endosperm: Implications for Seed Evolution.Molecular biology and evolution · 2025Article
- Introgression and Parental Conflict Shape Repeated Occurrences of Postzygotic Isolation.bioRxiv : the preprint server for biology · 2025Article
- Sex on Steroids: How Brassinosteroids Shape Reproductive Development in Flowering Plants.Plant & cell physiology · 2024Review
- United by conflict: Convergent signatures of parental conflict in angiosperms and placental mammals.The Journal of heredity · 2024Review
- Molecular basis and evolutionary drivers of endosperm-based hybridization barriers.Plant physiology · 2024Review
- Genetic and environmental manipulation ofFrontiers in plant science · 2023Article
- Abortion occurs during double fertilization and ovule development in Paeonia ludlowii.Journal of plant research · 2022Article
- The hybrid lethality of interspecific FMolecular breeding : new strategies in plant improvement · 2022Review
- Parental Genome Imbalance Causes Hybrid Seed Lethality as Well as Ovary Abscission in Interspecific and Interploidy Crosses inFrontiers in plant science · 2022Article
- Regulation of DNA Methylation During Plant Endosperm Development.Frontiers in genetics · 2022Review
- Sex-biased demography modulates male harm across the genome.Proceedings. Biological sciences · 2021Article
- Characterization of transcriptomic response in ovules derived from inter-subgeneric hybridization in Prunus (Rosaceae) species.Plant reproduction · 2021Article
- Transcriptional and imprinting complexity in Arabidopsis seeds at single-nucleus resolution.Nature plants · 2021Article
- Article
- The maternally expressed polycomb group genePlant communications · 2021Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hybrid seed failure represents an important postzygotic barrier to interbreeding among species of wild tomatoes (Solanum section Lycopersicon) and other flowering plants. We studied genome-wide changes associated with hybrid seed abortion in the closely related Solanum peruvianum and S. chilense where hybrid crosses yield high proportions of inviable seeds due to endosperm failure and arrested embryo development. Based on differences of seed size in reciprocal hybrid crosses and developmental evidence implicating endosperm failure, we hypothesized that perturbed genomic imprinting is involved in this strong postzygotic barrier. Consequently, we surveyed the transcriptomes of developing endosperms from intra- and inter-specific crosses using tissues isolated by laser-assisted microdissection. We implemented a novel approach to estimate parent-of-origin-specific expression using both homozygous and heterozygous nucleotide differences between parental individuals and identified candidate imprinted genes. Importantly, we uncovered systematic shifts of "normal" (intraspecific) maternal:paternal transcript proportions in hybrid endosperms; the average maternal proportion of gene expression increased in both crossing directions but was stronger with S. peruvianum in the maternal role. These genome-wide shifts almost entirely eliminated paternally expressed imprinted genes in S. peruvianum hybrid endosperm but also affected maternally expressed imprinted genes and all other assessed genes. These profound, systematic changes in parental expression proportions suggest that core processes of transcriptional regulation are functionally compromised in hybrid endosperm and contribute to hybrid seed failure.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.