ArticleMedical mycology2017
In Vitro activity of Manuka Honey and polyhexamethylene biguanide on filamentous fungi and toxicity to human cell lines.
Article in Medical mycology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- In-Vitro Effect of Manuka Honey / Propolis Toothpastes on Bacteria and Biofilm Associated with Caries and Gingivitis.Oral health & preventive dentistry · 2025Article
- Antimicrobial hydrogel foam dressing with controlled release of gallium maltolate for infection control in chronic wounds.Bioactive materials · 2024Article
- Preparation of N-Halamine Gelatin Sponge and Its Application in the Treatment of Skin Infection.Polymers · 2024Article
- Burn Wound Care Strategies for the Battlefield and Austere Settings.European burn journal · 2024Review
- Emerging Therapies in the Medical Management of Allergic Fungal Rhinosinusitis.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2024Article
- Effect of Commercially Available Wound Irrigation Solutions on Uninfected Host Tissue in a Murine Model.Arthroplasty today · 2024Article
- Antibacterial Efficacy of Manuka Honey-Doped Chitosan-Gelatin Cryogel and Hydrogel Scaffolds in Reducing Infection.Gels (Basel, Switzerland) · 2023Article
- Antiseptic Chitosan-Poly(hexamethylene) Biguanide Hydrogel for the Treatment of Infectious Wounds.Journal of functional biomaterials · 2023Article
- Multidrug-Resistant and Virulent Organisms Trauma Infections: Trauma Infectious Disease Outcomes Study Initiative.Military medicine · 2022Review
- The role of honey in the ecology of the hive: Nutrition, detoxification, longevity, and protection against hive pathogens.Frontiers in nutrition · 2022Review
- Update on the role of antiseptics in the management of chronic wounds with critical colonisation and/or biofilm.International wound journal · 2021Review
- Evolution of honey resistance in experimental populations of bacteria depends on the type of honey and has no major side effects for antibiotic susceptibility.Evolutionary applications · 2021Article
- Combat trauma-related invasive fungal wound infections.Current fungal infection reports · 2020Article
- Optimal Management of Allergic Fungal Rhinosinusitis.Journal of asthma and allergy · 2020Review
- Polyionic Complexed Antibacterial Heparin-Chitosan Particles for Antibiotic Delivery.ACS applied bio materials · 2019Article
- Anti-pseudomonad Activity of Manuka Honey and Antibiotics in a SpecializedFrontiers in microbiology · 2019Article
- The downside of antimicrobial agents for wound healing.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Review
- Re-thinking lactation-related nipple pain and damage.Women's health (London, England)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Soft-tissue invasive fungal infections are increasingly recognized as significant entities directly contributing to morbidity and mortality. They complicate clinical care, requiring aggressive surgical debridement and systemic antifungal therapy. To evaluate new topical approaches to therapy, we examined the antifungal activity and cytotoxicity of Manuka Honey (MH) and polyhexamethylene biguanide (PHMB). The activities of multiple concentrations of MH (40%, 60%, 80%) and PHMB (0.01%, 0.04%, 0.1%) against 13 clinical mould isolates were evaluated using a time-kill assay between 5 min and 24 h. Concentrations were selected to represent current clinical use. Cell viability was examined in parallel for human epidermal keratinocytes, dermal fibroblasts and osteoblasts, allowing determination of the 50% viability (LD50) concentration. Antifungal activity of both agents correlated more closely with exposure time than concentration. Exophiala and Fusarium growth was completely suppressed at 5 min for all PHMB concentrations, and at 12 and 6 h, respectively, for all MH concentrations. Only Lichtheimia had persistent growth to both agents at 24 h. Viability assays displayed concentration-and time-dependent toxicity for PHMB. For MH, exposure time predicted cytotoxicity only when all cell types were analyzed in aggregate. This study demonstrates that MH and PHMB possess primarily time-dependent antifungal activity, but also exert in vitro toxicity on human cells which may limit clinical use. Further research is needed to determine ideal treatment strategies to optimize antifungal activity against moulds while limiting cytotoxicity against host tissues in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.