Evidence map›Paper›PMID 27601233›Full record

ArticlePediatric surgery international2016

Diagnostic and prognostic values of serum exosomal microRNA-21 in children with hepatoblastoma: a Chinese population-based study.

Wanbo Liu, Sheng Chen, Bing Liu

Abstract read
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In one paragraph

Article in Pediatric surgery international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.

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  15. Exosomes as potential diagnosis and treatment for liver cancer.World journal of gastrointestinal oncology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Wanbo LiuDepartment of Medical Affairs, The General Hospital of the PLA Rocket Force, Beijing, China.
Sheng ChenDepartment of General Surgery, The General Hospital of the PLA Rocket Force, Beijing, China.
Bing LiuCenter for Disease Prevention and Control of Rocket Force, No. 109, Beiqing Road, Haidian distinct, Beijing, 100032, China. liubehbh@126.com.
Beijing Center for Disease Prevention and Control · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatoblastoma (HB) is the most common primary malignant tumor of the liver in young children. The aim of this study is to identify the diagnostic and prognostic values of serum exosomal miR-21 in Chinese patients with HB.

methodsWe retrospectively reviewed 32 children with HB. The expressions of miR-21 were detected by real-time PCR. The comparison of diagnostic performance of plasmatic, exosomal miR-21 and AFP levels was measured using the Area Under ROC Curve.

resultsFor patients in HB group, miR-21 concentration was significantly higher in the exosomes compared with the exosome-depleted supernatants and whole plasma. Expression of miR-21 was significantly higher in patients with HB compared with control group in both plasma and exosomes. With respect to the diagnosis of patients with HB, exosomal miR-21 was significantly more accurate compared with the Alpha-fetoprotein levels. Moreover, exosomal miR-21 was an independent predictor of Even-free survival for patients with HB.

conclusionsIn this study, we found that expression of miR-21 was significantly higher in patients with HB compared with control group in both plasma and exosomes, and we confirmed that exosomal miR-21 could be defined as a diagnostic and prognostic biomarker for patients with HB.

Indexed as

Biomarkers, TumorChild, PreschoolChinaExosomesFemaleHepatoblastomaHumansInfantLiver NeoplasmsMaleMicroRNAsPrognosisReal-Time Polymerase Chain ReactionRetrospective StudiesROC CurveBiomarkers, TumorMicroRNAsMIRN21 microRNA, humanExosomeHepatoblastomaMicroRNA-21

Identifiers

PMID27601233
OpenAlexW2520144838

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.