Evidence map›Paper›PMID 27601076›Full record

ArticleNature communications2016

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.

Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker, Kyriaki Michailidou, Jonathan Tyrer, Jonathan Beesley, Susan J Ramus, Qiyuan Li, Melissa K Delgado and 277 more

Erratum issuedOpen access · goldAbstract readAdaptive Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 60 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 3 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 3 syntheses or guidelines pooled it, 94 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. bioRxiv : the preprint server for biology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

287 authors at 20 institutions in 37 countries.

Kate Lawrenson *Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
Siddhartha Kar *Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Karen McCueQIMR Berghofer Medical Research Institute, Brisbane, 4029, Queensland, Australia.
Karoline KuchenbaekerDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Kyriaki MichailidouDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Jonathan TyrerDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Jonathan BeesleyQIMR Berghofer Medical Research Institute, Brisbane, 4029, Queensland, Australia.
Susan J RamusDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
Qiyuan LiMedical College, Xiamen University, Xiamen, 361102, China.
Melissa K DelgadoDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
Janet M LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, 00029 HUS, Finland.
Irene L AndrulisLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, M5G 1X5, Ontario, Canada.
Hoda Anton-CulverDepartment of Epidemiology, Genetic Epidemiology Research Institute, School of Medicine, University of California Irvine, Irvine, 92697, California, USA.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Banu K ArunUniversity of Texas MD Anderson Cancer Center, Houston, 77030, Texas, USA.
Brita ArverDepartment of Oncology, Karolinska University Hospital, Stockholm, 171 77, Sweden.
Elisa V BanderaCancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, 08903, New Jersey, USA.
Monica BarileDivision of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, 20141, Italy.
Rosa B BarkardottirDepartment of Pathology, Landspitali University Hospital and BMC (Biomedical Centre), Faculty of Medicine, University of Iceland, Reykjavik, 600169-2039, Iceland.
Daniel BarrowdaleDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, 91054, Germany.
Javier BenitezHuman Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, E-28029, Spain.
Andrew BerchuckDepartment of Obstetrics and Gynecology, Duke University Medical Center, Durham, 27710, North Carolina, USA.
Maria BisognaDepartment of Surgery, Gynecology Service, Memorial Sloan-Kettering Cancer Center, New York, 10065, USA.
Line BjorgeDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, 5021, Norway.
Carl BlomqvistDepartment of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, FIN-00029, Finland.
William BlotDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, 37203, Tennessee, USA.
Natalia BogdanovaGynaecology Research Unit, Hannover Medical School, Hannover, D-30625, Germany.
Anders BojesenDepartment of Clinical Genetics, Vejle Hospital, Vejle, 7100, Denmark.
Stig E BojesenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2200, Denmark.
Manjeet K BollaDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Bernardo BonanniDivision of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, 20141, Italy.
Anne-Lise Børresen-DaleDepartment of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, N-0310, Norway.
Hiltrud BrauchDr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, D-70376, Germany.
Paul BrennanInternational Agency for Research on Cancer, Lyon, 69008, France.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Fiona BruinsmaCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Victoria, Australia.
Joan BrunetGenetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, 08908, Spain.
Shaik Ahmad BuhariDepartment of Surgery, National University Health System, Singapore, 119077, Singapore.
Barbara BurwinkelMolecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Ralf ButzowDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland.
Saundra S BuysDepartment of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, 84112, Utah, USA.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, 37203, Tennessee, USA.
Trinidad CaldesMolecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, 28040, Spain.
Ian CampbellCancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, 3002, Victoria, Australia.
Rikki CanniotoDivision of Cancer Prevention and Population Sciences, Cancer Pathology & Prevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, 14263, New York, USA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69121, Germany.
Jocelyne ChiquetteUnité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec, Québec City, G1J 1Z4, Québec, Canada.
Ji-Yeob ChoiCancer Research Institute, Seoul National University, Seoul, 08826, Korea.
Kathleen B M ClaesCenter for Medical Genetics, Ghent University, Ghent, 9000, Belgium.
GEMO Study Collaborators
Linda S CookDivision of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, 87131, New Mexico, USA.
Angela CoxDepartment of Oncology, Sheffield Cancer Research, University of Sheffield, Sheffield, S10 2TN, UK.
Daniel W CramerHarvard HT Chan School of Public Health, Boston, 02115, Massachusetts, USA.
Simon S CrossDepartment of Neuroscience, Academic Unit of Pathology, University of Sheffield, Sheffield, S10 2TN, UK.
Cezary CybulskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, 70-115, Poland.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, 19111, Pennsylvania, USA.
Francesca DamiolaINSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, 69373, France.
Agnieszka Dansonka-MieszkowskaDepartment of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, 44-101, Poland.
Hatef DarabiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Joe DennisDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Peter DevileeDepartment of Pathology, Leiden University Medical Center, Leiden, 2333, The Netherlands.
Orland DiezOncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona, Barcelona, 08035, Spain.
Jennifer A DohertyDepartment of Community and Family Medicine, Section of Biostatistics & Epidemiology, The Geisel School of Medicine at Dartmouth, Lebanon, 03755, New Hampshire, USA.
Susan M DomchekDepartment of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA.
Cecilia M DorflingDepartment of Genetics, University of Pretoria, Pretoria, 0083, South Africa.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, D-30625, Germany.
Martine DumontGenomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, G1V 4G2, Québec, Canada.
Hans EhrencronaDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, 751 05, Sweden.
Bent EjlertsenDepartment of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
Steve EllisDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
EMBRACE
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, 04107, Germany.
Eunjung LeeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
D Gareth EvansGenomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, M13 9PL, UK.
Peter A FaschingDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, 91054, Germany.
Lidia FeliubadaloMolecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute),Catalan Institute of Oncology, Barcelona, 08908, Spain.
Jonine FigueroaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, 20892, Maryland, USA.
Dieter Flesch-JanysInstitute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, 20246, Germany.
Olivia FletcherBreakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
Henrik FlygerDepartment of Breast Surgery, Herlev Hospital, Copenhagen University Hospital, Herlev, 2730, Denmark.
Lenka ForetovaMasaryk Memorial Cancer Institute and Medical Faculty MU, Brno, 625 00, Czech Republic.
Florentia FostiraMolecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, 153 10, Greece.
William D FoulkesDepartments of Human Genetics and Oncology, Program in Cancer Genetics, McGill University, Montreal, Montreal, H2W 1S6, Quebec, Canada.
Brooke L FridleyBiostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, 66160, Kansas, USA.
Eitan FriedmanSusanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, 52621, Israel.
Debra FrostDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Gaetana GambinoDepartment of Laboratory Medicine, Section of Genetic Oncology, University and University Hospital of Pisa, Pisa, 56126, Italy.
Patricia A GanzDivision of Cancer Prevention & Control Research, UCLA Schools of Medicine and Public Health, Jonsson Comprehensive Cancer Center, Los Angeles, 90024, California, USA.
Judy GarberCancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA.
Montserrat García-ClosasDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, 20892, Maryland, USA.
Aleksandra Gentry-MaharajWomen's Cancer, UCL EGA Institute for Women's Health, London, WC1E 6AU, UK.
Maya GhoussainiDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Graham G GilesCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Victoria, Australia.
Rosalind GlasspoolCancer Research UK Clinical Trials Unit, The Beatson West of Scotland Cancer Centre, Glasgow, G12 0YN, UK.
Andrew K GodwinDepartment of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, 66160, Kansas, USA.
Mark S GoldbergDivision of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, H3A 1A1, Québec, Canada.
David E GoldgarDepartment of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, 84132, Utah, USA.
Anna González-NeiraHuman Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, E-28029, Spain.
Ellen L GoodeDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55902, Minnesota, USA.
Marc T GoodmanCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA.
Mark H GreeneDivision of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Rockville, 20892, Maryland, USA.
Jacek GronwaldDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, 70-204, Poland.
Pascal GuénelEnvironmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, 94805, France.
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Emily HallbergDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55902, Minnesota, USA.
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Thomas V O HansenCenter for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, 2100, Denmark.
Patricia A HarringtonDepartment of Oncology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, CB1 8RN, UK.
Mikael HartmanDepartment of Surgery, National University Health System, Singapore, 119077, Singapore.
Norhashimah HassanBreast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, 50603, Malaysia.
Sue HealeyQIMR Berghofer Medical Research Institute, Brisbane, 4029, Queensland, Australia.
Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON)
Florian HeitzDepartment of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, 45136, Germany.
Josef HerzogClinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, 91010, California, USA.
Estrid HøgdallDepartment of Pathology, Molecular Unit, Herlev Hospital, University of Copenhagen, Copenhagen, 2730, Denmark.
Claus K HøgdallDepartment of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, 2100, Denmark.
Frans B L HogervorstFamily Cancer Clinic, Netherlands Cancer Institute, Amsterdam, 1006, The Netherlands.
Antoinette HollestelleDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, 3015, The Netherlands.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, 3010, Victoria, Australia.
Peter J HulickCenter for Medical Genetics, NorthShore University Health System, Evanston, 60201, Illinois, USA.
Tomasz HuzarskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, 70-115, Poland.
Evgeny N ImyanitovN.N. Petrov Institute of Oncology, St Petersburg, 197758, Russia.
KConFab Investigators
Australian Ovarian Cancer Study Group
Claudine IsaacsLombardi Comprehensive Cancer Center, Georgetown University, Washington, 20057, District of Columbia, USA.
Hidemi ItoDivision of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Aichi, 464-8681, Japan.
Anna JakubowskaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, 70-115, Poland.
Ramunas JanaviciusState Research Institute Centre for Innovative Medicine, Vilnius, LT-01102, Lithuania.
Allan JensenDepartment of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, 2100, Denmark.
Esther M JohnDepartment of Epidemiology, Cancer Prevention Institute of California, Fremont, 94538, California, USA.
Nichola JohnsonBreakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
Maria KabischMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Daehee KangCancer Research Institute, Seoul National University, Seoul, 08826, Korea.
Miroslav KapuscinskiCentre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, 3010, Victoria, Australia.
Beth Y KarlanWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA.
Sofia KhanDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland.
Lambertus A KiemeneyRadboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, 6500, The Netherlands.
Susanne Kruger KjaerDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, DK-2100, Denmark.
Julia A KnightProsserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, M5G 1X5, Ontario, Canada.
Irene KonstantopoulouMolecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, 153 10, Greece.
Veli-Matti KosmaDepartment of Clinical Pathology, Imaging Center, Kuopio University Hospital, Kuopio, 70210, Finland.
Vessela KristensenDepartment of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, N-0310, Norway.
Jolanta KupryjanczykDepartment of Pathology and Laboratory Diagnostics the Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, 44-101, Poland.
Ava KwongThe Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong, China.
Miguel de la HoyaMolecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, 28040, Spain.
Yael LaitmanSusanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel-Hashomer, 52621, Israel.
Diether LambrechtsVesalius Research Center, VIB, Leuven, 3000, Belgium.
Nhu LeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
Kim De LeeneerCenter for Medical Genetics, Ghent University, Ghent, 9000, Belgium.
Jenny LesterWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, 90048, California, USA.
Douglas A LevineDepartment of Surgery, Gynecology Service, Memorial Sloan-Kettering Cancer Center, New York, 10065, USA.
Jingmei LiDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, 37203, Tennessee, USA.
Artitaya LophatananonDivision of Health Sciences, Warwick Medical School, Warwick University, Coventry, CV4 7AL, UK.
Jennifer T LoudDivision of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Rockville, 20892, Maryland, USA.
Karen LuDepartment of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, 77030, Texas, USA.
Jan LubinskiDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, 70-115, Poland.
Arto MannermaaDepartment of Clinical Pathology, Imaging Center, Kuopio University Hospital, Kuopio, 70210, Finland.
Siranoush ManoukianDepartment of Preventive and Predictive Medicine, Unit of Medical Genetics, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, 20133, Italy.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, 96813, Hawaii, USA.
Sara MargolinDepartment of Oncology - Pathology, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Frederik MarmeDepartment of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, 69120, Germany.
Leon F A G MassugerDepartment of Gynaecology, Radboud University Medical Centre, Nijmegen, 6500, The Netherlands.
Keitaro MatsuoDepartment of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, 812-8582, Japan.
Sylvie MazoyerINSERM U1052, CNRS UMR5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, 69373, France.
Lesley McGuffogDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Catriona McLeanAnatomical Pathology, The Alfred Hospital, Melbourne, 3004, Victoria, Australia.
Iain McNeishInstitute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, G61 1BD, UK.
Alfons MeindlDivision of Gynaecology and Obstetrics, Technische Universität München, Munich, 81675, Germany.
Usha MenonWomen's Cancer, UCL EGA Institute for Women's Health, London, WC1E 6AU, UK.
Arjen R MensenkampDepartment of Human Genetics, Radboud University Medical Centre, Nijmegen, 6500, The Netherlands.
Roger L MilneCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, 3004, Victoria, Australia.
Marco MontagnaImmunology and Molecular Oncology Unit, Instituto Oncologico Veneto IOV, IRCCS, Padua, 35128, Italy.
Kirsten B MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, 14263, New York, USA.
Kenneth MuirDivision of Health Sciences, Warwick Medical School, Warwick University, Coventry, CV4 7AL, UK.
Anna Marie MulliganLaboratory Medicine Program, University Health Network, Toronto, M5G 1L7, Ontario, Canada.
Katherine L NathansonDepartment of Medicine, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA.
Roberta B NessThe University of Texas School of Public Health, Houston, 77030, Texas, USA.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, 91010, California, USA.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, 00029 HUS, Finland.
Silje NordK.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, N-0310, Norway.
Robert L NussbaumDepartment of Medicine and Genetics, University of California, San Francisco, 94143, California, USA.
Kunle OdunsiDepartment of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, 14263, New York, USA.
Kenneth OffitDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, 10065, USA.
Edith OlahDepartment of Molecular Genetics, National Institute of Oncology, Budapest, 1122, Hungary.
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, 60637, Illinois, USA.
Janet E OlsonDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55902, Minnesota, USA.
Curtis OlswoldDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55902, Minnesota, USA.
David O'MalleyThe Ohio State University and the James Cancer Center, Columbus, 43210, Ohio, USA.
Irene OrlowDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, 10017, USA.
Nick OrrBreakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, SW3 6JB, UK.
Ana OsorioHuman Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, 28019, Spain.
Sue Kyung ParkDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul, 03080, Korea.
Celeste L PearceDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
Tanja PejovicDepartment of Obstetrics and Gynecology, Oregon Health and Science University, Portland, 97239, Oregon, USA.
Paolo PeterlongoIFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, 16 20139, Italy.
Georg PfeilerDepartment of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria.
Catherine M PhelanDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, 33606, Florida, USA.
Elizabeth M PooleChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, 02115, Massachusetts, USA.
Katri PylkäsLaboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab, Oulu, FI-90014, Finland.
Paolo RadiceDepartment of Preventive and Predictive Medicine, Unit of Molecular Bases of Genetic Risk and Genetic Testing, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, 20133, Italy.
Johanna RantalaDepartment of Clinical Genetics, Karolinska University Hospital, Stockholm, 171 76, Sweden.
Muhammad Usman RashidMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Gad RennertClalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Haifa, 34362, Israel.
Valerie RheniusDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Kerstin RhiemDepartment of Gynaecology and Obstetrics and Centre for Integrated Oncology (CIO), Centre of Familial Breast and Ovarian Cancer, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, 50931, Germany.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, 06510, Connecticut, USA.
Gus RodriguezDivision of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, 60201, Illinois, USA.
Mary Anne RossingDivision of Public Health Sciences, Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, 98109, Washington, USA.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69121, Germany.
Helga B SalvesenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, 5021, Norway.
Suleeporn SangrajrangNational Cancer Institute, Bangkok, 10400, Thailand.
Elinor J SawyerResearch Oncology, Guy's Hospital, King's College London, London, SE1 9RT, UK.
Joellen M SchildkrautDepartment of Community and Family Medicine, Duke University Medical Center, Durham, 27710, North Carolina, USA.
Marjanka K SchmidtNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, 1066 CX, The Netherlands.
Rita K SchmutzlerDivision of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, University Hospital of Cologne, Cologne, 50676, Germany.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, 33606, Florida, USA.
Caroline SeynaeveDepartment of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, 3015, The Netherlands.
Mitul ShahDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Chen-Yang ShenTaiwan Biobank, Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, 37203, Tennessee, USA.
Weiva SiehDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, 94305, California, USA.
Christian F SingerDepartment of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria.
Olga M SinilnikovaUnité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon - Centre Léon Bérard, Lyon, 69008, France.
Susan SlagerDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55902, Minnesota, USA.
Honglin SongDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Penny SoucyGenomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, G1V 4G2, Québec, Canada.
Melissa C SoutheyDepartment of Pathology, University of Melbourne, Parkville, 3010, Victoria, Australia.
Marie Stenmark-AskmalmDepartment of Clinical Genetics, Lund University Hospital, Lund, 221 00, Sweden.
Dominique Stoppa-LyonnetInstitut Curie, Department of Tumour Biology, Paris, France; Department of Tumour Biology, Institut Curie, Paris, France.
Christian SutterDepartment of Human Genetics, Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, 69120, Germany.
Anthony SwerdlowDivision of Breast Cancer Research, The Institute of Cancer Research, London, SW7 3RP, UK.
Sandrine TchatchouLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, M5G 1X5, Ontario, Canada.
Manuel R TeixeiraDepartment of Genetics, Portuguese Oncology Institute, Porto, 4200-072, Portugal.
Soo H TeoBreast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, 50603, Malaysia.
Kathryn L TerryHarvard HT Chan School of Public Health, Boston, 02115, Massachusetts, USA.
Mary Beth TerryDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, 10027, USA.
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, Odense C, 5000, Denmark.
Maria Grazia TibilettiUO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Varese, 21100, Italy.
Laima TihomirovaLatvian Biomedical Research and Study Centre, Riga, LV-1067, Latvia.
Silvia TognazzoImmunology and Molecular Oncology Unit, Istituto Oncologico Veneto IOV - IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico), Padua, 64 - 35128, Italy.
Amanda Ewart TolandDepartment of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, 43210, Ohio, USA.
Ian TomlinsonWellcome Trust Centre for Human Genetics and Oxford Biomedical Research Centre, University of Oxford, Oxford, OX3 7BN, UK.
Diana TorresMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, 69120, Germany.
Thérèse TruongEnvironmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, 94805, France.
Chiu-Chen TsengDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
Nadine TungDepartment of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, 02215, Massachusetts, USA.
Shelley S TworogerChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, 02115, Massachusetts, USA.
Celine VachonDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55902, Minnesota, USA.
Ans M W van den OuwelandDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, 3015 CE, The Netherlands.
Helena C van DoornDepartment of Gynecology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, 3015 CE, The Netherlands.
Elizabeth J van RensburgDepartment of Genetics, University of Pretoria, Pretoria, 0083, South Africa.
Laura J Van't VeerNetherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, 1066 CX, The Netherlands.
Adriaan VandersticheleDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, B-3000, Belgium.
Ignace VergoteDivision of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, B-3000, Belgium.
Joseph VijaiDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, 10065, USA.
Qin WangDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Shan Wang-Gohrkeuniversity hospital ulm, Ulm, 89069, Germany.
Jeffrey N WeitzelClinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, 91010, California, USA.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, 20892, Maryland, USA.
Alice S WhittemoreDepartment of Health Research and Policy - Epidemiology, Stanford University School of Medicine, Stanford, 94305, California, USA.
Hans WildiersDepartment of General Medical Oncology, Multidisciplinary Breast Center, University Hospitals Leuven, Leuven, B-3000, Belgium.
Robert WinqvistLaboratory of Cancer Genetics and Tumour Biology, Northern Finland Laboratory Centre NordLab, Oulu, FI-90014, Finland.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
Drakoulis YannoukakosMolecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research 'Demokritos', Athens, 153 10, Greece.
Sook-Yee YoonCancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, 47500, Malaysia.
Jyh-Cherng YuDepartment of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, 114, Taiwan.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, 37203, Tennessee, USA.
Ying ZhengShanghai Center for Disease Control and Prevention, Shanghai, China.
Kum Kum KhannaQIMR Berghofer Medical Research Institute, Brisbane, 4029, Queensland, Australia.
Jacques SimardGenomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, G1V 4G2, Québec, Canada.
Alvaro N MonteiroDivision of Population Sciences, Cancer Epidemiology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, 33612, Florida, USA.
Juliet D FrenchQIMR Berghofer Medical Research Institute, Brisbane, 4029, Queensland, Australia.
Fergus J CouchDepartment of Health Sciences Research, Mayo Clinic, Rochester, 55902, Minnesota, USA.
Matthew L FreedmanDepartment of Medical Oncology, The Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, 02215, Massachusetts, USA.
Douglas F EastonDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Alison M DunningDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Paul D PharoahDepartment of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
Stacey L EdwardsQIMR Berghofer Medical Research Institute, Brisbane, 4029, Queensland, Australia.
Georgia Chenevix-TrenchQIMR Berghofer Medical Research Institute, Brisbane, 4029, Queensland, Australia.
Antonis C AntoniouDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK. aca20@medschl.cam.ac.uk.
Simon A GaytherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, 90033, California, USA.
University of Cambridge · GBUniversity of Southern California · USInstitut Curie · FRGerman Cancer Research Center · DEQIMR Berghofer Medical Research Institute · AUBrigham and Women's Hospital · USInstitute of Cancer Research · GBMemorial Sloan Kettering Cancer Center · USUniversity of Copenhagen · DKCedars-Sinai Medical Center · USCentre Georges François Leclerc · FRRadboud University Nijmegen · NLThe Netherlands Cancer Institute · NLUniversité Claude Bernard Lyon 1 · FRVanderbilt University · USInstitut Bergonié · FRNational Centre of Scientific Research "Demokritos" · GRRoswell Park Comprehensive Cancer Center · USThe University of Melbourne · AUUniversity Malaya Medical Centre · MY

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MATTHEW J TYSKA · 1995 to 2026
$172.8M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Statistics CoreU10CA180822 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI James J. Dignam · 2014 to 2026
$146.4M
NRG Oncology NCORP Research Base-BIQSFPUG1CA189867 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Deborah Watkins Bruner, Lisa A. Kachnic · 2014 to 2026
$140.5M
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
GYNECOLOGIC ONCOLOGY GROUP HEADQUARTERSU10CA027469 · NCI · GYNECOLOGIC ONCOLOGY GROUP · PI DISAIA, PHILIP J. · 1985 to 2013
$132.6M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Cancer Research UK 10118Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 11174Cancer Research UK 16459Cancer Research UK 16561Cancer Research UK 16565Cancer Research UK 20861Medical Research Council G0501974NCATS NIH HHS UL1 TR000124NCI NIH HHS K07 CA092044NCI NIH HHS K07 CA095666NCI NIH HHS K07 CA143047NCI NIH HHS K22 CA138563NCI NIH HHS K99 CA184415NCI NIH HHS N01 CN025403NCI NIH HHS N01 PC067010NCI NIH HHS N02 CP011019NCI NIH HHS N02 CP065504NCI NIH HHS P01 CA017054NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA051008NCI NIH HHS P30 CA068485NCI NIH HHS P30 CA168524NCI NIH HHS P50 CA105009NCI NIH HHS P50 CA116201NCI NIH HHS P50 CA125183NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01 CA054419NCI NIH HHS R01 CA058598NCI NIH HHS R01 CA058860NCI NIH HHS R01 CA063678NCI NIH HHS R01 CA063682NCI NIH HHS R01 CA064277NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA074850NCI NIH HHS R01 CA076016NCI NIH HHS R01 CA077398NCI NIH HHS R01 CA080742NCI NIH HHS R01 CA083855NCI NIH HHS R01 CA083918NCI NIH HHS R01 CA087538NCI NIH HHS R01 CA087696NCI NIH HHS R01 CA100374NCI NIH HHS R01 CA102776NCI NIH HHS R01 CA106414NCI NIH HHS R01 CA112523NCI NIH HHS R01 CA114343NCI NIH HHS R01 CA116167NCI NIH HHS R01 CA122443NCI NIH HHS R01 CA126841NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA136924NCI NIH HHS R01 CA140323NCI NIH HHS R01 CA142996NCI NIH HHS R01 CA148667NCI NIH HHS R01 CA149429NCI NIH HHS R01 CA176785NCI NIH HHS R01 CA259058NCI NIH HHS R03 CA113148NCI NIH HHS R03 CA115195NCI NIH HHS R37 CA070867NCI NIH HHS RC4 CA153828NCI NIH HHS U01 CA069417NCI NIH HHS U01 CA113916NCI NIH HHS U01 CA116167NCI NIH HHS U01 CA161032NCI NIH HHS U10 CA027469NCI NIH HHS U10 CA037517NCI NIH HHS U10 CA101165NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UM1 CA164920Wellcome TrustWorld Health Organization 001
6 · The paper itself

Abstract

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10(-20)), ER-negative BC (P=1.1 × 10(-13)), BRCA1-associated BC (P=7.7 × 10(-16)) and triple negative BC (P-diff=2 × 10(-5)). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10(-3)) and ABHD8 (P<2 × 10(-3)). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3'-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk.

Indexed as

AllelesGenetic Predisposition to DiseasePolymorphism, Single NucleotideAsian PeopleBlack PeopleBreast NeoplasmsChromosomes, Human, Pair 19FemaleGenome-Wide Association StudyGenotypeHumansOvarian NeoplasmsRNA, MessengerRNA, Messenger

Identifiers

PMID27601076
PMCPMC5023955
OpenAlexW2412990135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.