Evidence map›Paper›PMID 27600882›Full record

ArticleJournal of biophotonics2017

Tail artifact removal in OCT angiography images of rodent cortex.

Utku Baran, Woo June Choi, Yuandong Li, Ruikang K Wang

Open access · greenAbstract read
In one paragraph

Article in Journal of biophotonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Quantification of Normative Human Choriocapillaris Measures Across the Macula.Investigative ophthalmology & visual science · 2025
    Article
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  5. Article
  6. ImprovedJournal of biomedical optics · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020
    Article
  13. Cerebral edema detectionNeurophotonics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Utku BaranDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Woo June ChoiDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Yuandong LiDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Ruikang K WangDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
University of Washington · US

Funding

OPTICAL MICROANGIOGRAHY OF CEREBROVASCULAR PERFUSIONR01HL093140 · NHLBI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2008 to 2017
$4.2M
Label-free optical imaging of 3D structural and functional microcirculationsR01EB009682 · NIBIB · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2009 to 2012
$1.7M
NHLBI NIH HHS R01 HL093140NIBIB NIH HHS R01 EB009682
6 · The paper itself

Abstract

Optical coherence tomography angiography (OCTA) is a surging non-invasive, label-free, in vivo volumetric imaging method, currently being translated to clinical ophthalmology and becoming popular in neuroscience. Despite its attractiveness, there is an inherent issue of using OCT angiograms for quantitative cerebrovascular studies: The dynamic scattering of moving erythrocytes within pial vasculature creates tail-like artifacts that shadow the capillary vessels in the deeper layers of cortex. This false flow effect is relatively benign for qualitative visualization purposes, but it might have a significant impact on quantitative interpretation of angiographic results. In this work, we propose a simple image processing method to remove these tail artifacts in depth-resolved OCTA images using an adaptive enface mask generated with OCT structural images. We demonstrate the effectiveness of our method by comparing vessel densities and vessel similarities of depth-resolved OCT angiograms in a stroke study in a rodent model, in vivo. Thanks to the ability of seeing through the tails of pial vessels, capillary vessels beneath these vessels could be recovered to some extend in the deeper layers of mouse cerebral cortex, leading to a more accurate quantification. Tail artifact removed enface OCT angiogram of deeper layer in vivo mouse cortex.

Indexed as

AngiographyArtifactsTomography, Optical CoherenceAnimalsBrain IschemiaCerebral CortexImage Processing, Computer-AssistedMaleMiceSignal-To-Noise Ratioartifact removalOCT angiographyoptical coherence tomographystroke

Identifiers

PMID27600882
PMCPMC5340634
OpenAlexW2510514201

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.