ArticleMolecular medicine reports2016
Antiviral activities of atractylon from Atractylodis Rhizoma.
Article in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Atractylodis Rhizoma: A review of its traditional uses, phytochemistry, pharmacology, toxicology and quality control.Journal of ethnopharmacology · 2021Pooled it
- Meta-Analysis on the Chinese Herbal FormulaFrontiers in pharmacology · 2020Pooled it
- A randomized placebo-controlled phase I clinical trial to evaluate the immunomodulatory activities of Atractylodes lancea (Thunb) DC. in healthy Thai subjects.BMC complementary medicine and therapies · 2021Trial
- Integrated Transcriptomic and Metabolomic Analyses Reveal the Mechanism by Which 5-Methoxyindole Enhances Sesquiterpenoids Production inPlants (Basel, Switzerland) · 2026Article
- A Systematic Review on Functional Bioactive Compound Atractylone: Natural Source, Pharmacological Properties and Mechanisms Insights.Food science & nutrition · 2026Review
- Characterisation of Early Biosynthetic Steps of Atractylon via an Integrative Strategy.Plant biotechnology journal · 2025Article
- Transcriptome-wide analysis of AlbHLH gene family in Atractylodes lancea (Thunb.) DC and functional exploration of AlbHLH3 in regulating terpenoid biosynthesis.BMC plant biology · 2025Article
- Study on the Mechanism of RuHaoDaShi Granules in Treating H1N1 Viral Pneumonia Based on Network Pharmacology and Experimental Validation.Pathogens (Basel, Switzerland) · 2025Article
- Advancements in the therapeutic potential of sesquiterpenoids for the treatment of hepatocellular carcinoma (Review).International journal of oncology · 2025Review
- Atractylenolide I Suppresses A1 Astrocyte Activation to Improve Depression in Mice.Molecular neurobiology · 2024Article
- Phytochemistry and Pharmacology of Sesquiterpenoids fromMolecules (Basel, Switzerland) · 2024Review
- Targeting programmed cell death via active ingredients from natural plants: a promising approach to cancer therapy.Frontiers in pharmacology · 2024Review
- The biological function ofFrontiers in veterinary science · 2024Review
- Efficacy, Safety and Economic Evaluation of Wolbigachul-Tang for Chronic Cough Due to Upper Airway Cough Syndrome (UACS): A Study Protocol for Randomized, Double-Blind, Active-Comparator Controlled, Parallel, Exploratory Clinical Trial.Healthcare (Basel, Switzerland) · 2023Article
- Geographic Differentiation of Essential Oil from Rhizome of CultivatedMolecules (Basel, Switzerland) · 2023Article
- Network Pharmacology and Experimental Validation to Investigate the Antidepressant Potential ofLife (Basel, Switzerland) · 2022Article
- In vitro production of atractylon and β-eudesmol from Atractylodes chinensis by adventitious root culture.Applied microbiology and biotechnology · 2022Article
- Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments.Journal of neuroinflammation · 2022Review
- Molecular mechanism of atractylon in the invasion and migration of hepatic cancer cells based on high‑throughput sequencing.Molecular medicine reports · 2022Article
- Atractylon inhibits the tumorigenesis of glioblastoma through SIRT3 signaling.American journal of cancer research · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atractylodis Rhizoma is a traditional medicinal herb, which has antibacterial, antiviral, anti‑inflammatory and anti‑allergic, anticancer, gastroprotective and neuroprotective activities. It is widely used for treating fever, cold, phlegm, edema and arthralgia syndrome in South‑East Asian nations. In this study, 6 chemical compositions of Atractylodis Rhizoma were characterized by spectral analysis and their antiviral activities were evaluated in vitro and in vivo. Among them, atractylon showed most significant antiviral activities. Atractylon treatment at doses of 10‑40 mg/kg for 5 days attenuated influenza A virus (IAV)‑induced pulmonary injury and decreased the serum levels of interleukin (IL)‑6, tumor necrosis factor‑α and IL‑1β, but increased interferon‑β (IFN‑β) levels. Atractylon treatment upregulated the expression of Τoll‑like receptor 7 (TLR7), MyD88, tumor necrosis factor receptor‑associated factor 6 and IFN‑β mRNA but downregulated nuclear factor‑κB p65 protein expression in the lung tissues of IAV‑infected mice. These results demonstrated that atractylon significantly alleviated IAV‑induced lung injury via regulating the TLR7 signaling pathway, and may warrant further evaluation as a possible agent for IAV treatment.
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