ArticleMolecular medicine reports2016
Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction.
Article in Molecular medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- The Effect of Curcumin on Chronic Toxoplasma gondii Infection in the Testes of BALB/c Mice.Acta parasitologica · 2026Article
- Exploring the causal associations between obesity indicators and male reproductive diseases: new evidence from Mendelian randomization.Basic and clinical andrology · 2025Article
- Deoxycholic Acid Impairs Human Sperm Quality and Function Through Oxidative Stress-Driven Damage.Antioxidants (Basel, Switzerland) · 2025Article
- Effects of Physical Activity on Fertility Parameters: A Meta-Analysis of Randomized Controlled Trials.The world journal of men's health · 2024Article
- Pathophysiology of obesity-related infertility and its prevention and treatment by potential phytotherapeutics.International journal of obesity (2005) · 2024Review
- Curcumin Remedies Testicular Function and Spermatogenesis in Male Mice with Low-Carbohydrate-Diet-Induced Metabolic Dysfunction.International journal of molecular sciences · 2022Article
- Comparative Evaluation of the Parameters of Sperm Apoptosis of Young and Middle-Aged Men by Flow Cytometry.Bulletin of experimental biology and medicine · 2022Article
- Irisin alleviates obesity-related spermatogenesis dysfunction via the regulation of the AMPKα signalling pathway.Reproductive biology and endocrinology : RB&E · 2021Article
- Association Between Body Mass Index and Male Sperm Apoptosis and Apoptosis-Related Factors.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Protective Effects of Curcumin in the Reproductive System: Anti-toxic, Semen Cryopreservative, and Contraceptive Actions.Advances in experimental medicine and biology · 2021Review
- Curcumin protects against palmitic acid-induced apoptosis via the inhibition of endoplasmic reticulum stress in testicular Leydig cells.Reproductive biology and endocrinology : RB&E · 2019Article
- Grape seed proanthocyanidin extract alleviates high-fat diet induced testicular toxicity in rats.RSC advances · 2019Article
- Metabolic treatment of syndrome linked with Parkinson's disease and hypothalamus pituitary gonadal hormones by turmeric curcumin in Bisphenol-A induced neuro-testicular dysfunction of wistar rat.Biochemistry and biophysics reports · 2019Article
- Article
- In Utero and Postnatal Exposure to High Fat, High Sucrose Diet Suppressed Testis Apoptosis and Reduced Sperm Count.Scientific reports · 2018Article
- Diet-induced obesity impairs spermatogenesis: a potential role for autophagy.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curcumin, a type of natural active ingredient, is derived from rhizoma of Curcuma, which possesses antioxidant, antitumorigenic and anti‑inflammatory activities. The present study aimed to investigate whether treatment with curcumin reduced high‑fat diet (HFD)‑induced spermatogenesis dysfunction. Sprague‑Dawley rats fed a HFD were treated with or without curcumin for 8 weeks. The testis/body weight, histological analysis and serum hormone levels were used to evaluate the effects of curcumin treatment on spermatogenesis dysfunction induced by the HFD. In addition, the expression levels of apoptosis associated proteins, Fas, B‑cell lymphoma (Bcl)‑xl, Bcl‑associated X protein (Bax) and cleaved‑caspase 3, were determined in the testis. The results of the present study suggested that curcumin treatment attenuated decreased testis/body weight and abnormal hormone levels. Morphological changes induced by a HFD were characterized as atrophied seminiferous tubules, decreased spermatogenetic cells and interstitial cells were improved by curcumin treatment. In addition, curcumin treatment reduced apoptosis in the testis, and decreased expression of Fas, Bax and cleaved‑caspase 3, as well as increased expression of Bcl‑xl. In conclusion, the present study revealed that curcumin treatment reduced HFD‑induced spermatogenesis dysfunction in male rats.
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