Evidence map›Paper›PMID 27600681›Full record

ReviewTrends in immunology2016

Balancing Tolerance or Allergy to Food Proteins.

Paul J Bryce

Open access · greenAbstract readReview
In one paragraph

Review in Trends in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Neutrophil-activating protein inFrontiers in immunology · 2024
    Article
  3. International journal of molecular sciences · 2023
    Article
  4. Oral immunotherapy with omalizumab reverses the Th2 cell-like programme of regulatory T cells and restores their function.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018
    Article
  5. Article
  6. Review
  7. Childhood food allergies: An evolutionary mismatch hypothesis.Evolution, medicine, and public health · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Paul J BryceDivision of Allergy-Immunology, Department of Medicine, Northwestern Feinberg School of Medicine, 240 East Huron, Chicago, IL 60611, USA. Electronic address: p-bryce@northwestern.edu.
Northwestern University · US

Funding

Regulation of T cell migration by histamineR01AI076456 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI HULSE, KATHRYN ELIZABETH · 2008 to 2017
$3.9M
Regulation of food allergy and anaphylaxis by IL 33R01AI105839 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BOCHNER, BRUCE S · 2014 to 2018
$1.8M
NIAID NIH HHS R01 AI076456NIAID NIH HHS R01 AI105839
6 · The paper itself

Abstract

Dietary proteins usually induce immune tolerance, but may trigger life-threatening immune responses in the case of food allergy. The associated type 2 immunity, linked with specific IgE production and the activation of mast cells and basophils, is well understood but the mechanisms related to preventing food allergy are still being deciphered. Recent insights into the mechanisms that regulate oral tolerance and dietary antigen sampling have revealed unique regulatory events that occur during early life and into adulthood. Drawing from both recent clinical and experimental discoveries, this article focuses on current evidence for how several key stages of life present mechanistic points that might participate in tipping the balance between food protein tolerance and allergy.

Indexed as

AdultAllergensAnimalsBasophilsCell DegranulationChildCytokinesDietary ProteinsFood HypersensitivityHumansImmune ToleranceImmunoglobulin EMast CellsTh2 CellsT-Lymphocytes, RegulatoryAllergensCytokinesDietary ProteinsImmunoglobulin E

Identifiers

PMID27600681
PMCPMC5048554
OpenAlexW2509887081

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.