ArticleTissue engineering. Part A2016
Human Corneal Fibroblast Pattern Evolution and Matrix Synthesis on Mechanically Biased Substrates.
Article in Tissue engineering. Part A, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The Effects of Eye Rubbing on Corneal Topography and Biomechanics in Children With Allergic Conjunctivitis.Translational vision science & technology · 2025Observational
- Article
- Measuring collagen fibril diameter with differential interference contrast microscopy.Journal of structural biology · 2021Article
- Methods for Investigating Corneal Cell Interactions and Extracellular Vesicles In Vitro.Current protocols in cell biology · 2020Article
- Keratocyte mechanobiology.Experimental eye research · 2020Review
- Three-dimensional collagen fiber mapping and tractography of human uterine tissue using OCT.Biomedical optics express · 2020Article
- High-speed collagen fiber modeling and orientation quantification for optical coherence tomography imaging.Optics express · 2019Article
- Cell regulation of collagen fibril macrostructure during corneal morphogenesis.Acta biomaterialia · 2018Article
- Assessment of Corneal Stromal Remodeling and Regeneration after Photorefractive Keratectomy.Scientific reports · 2018Article
- Frequency-constrained robust principal component analysis: a sparse representation approach to segmentation of dynamic features in optical coherence tomography imaging.Optics express · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
In a fibroblast colony model of corneal stromal development, we asked how physiological tension influences the patterning dynamics of fibroblasts and the orientation of deposited extracellular matrix (ECM). Using long-term live-cell microscopy, enabled by an optically accessible mechanobioreactor, a primary human corneal fibroblast colony was cultured on three types of substrates: a mechanically biased, loaded, dense, disorganized collagen substrate (LDDCS), a glass coverslip, and an unloaded, dense, disorganized collagen substrate (UDDCS). On LDDCS, fibroblast orientation and migration along a preferred angle developed early, cell orientation was correlated over long distances, and the colony pattern was stable. On glass, fibroblast orientation was poorly correlated, developed more slowly, and colony patterns were metastable. On UDDCS, cell orientation was correlated over shorter distances compared with LDDCS specimens. On all substrates, the ECM pattern reflected the cell pattern. In summary, mechanically biasing the collagen substrate altered the early migration behavior of individual cells, leading to stable emergent cell patterning, which set the template for newly synthesized ECM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.