ArticleJournal of the American Society for Mass Spectrometry2016
Improving the Molecular Ion Signal Intensity for In Situ Liquid SIMS Analysis.
Article in Journal of the American Society for Mass Spectrometry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Molecular imaging of bacterial biofilms-a systematic review.Critical reviews in microbiology · 2024Pooled it
- TOF-SIMS Imaging of Intact Lipids in Biological Tissue with Enhanced Ion Intensity by Ionic Liquid.ACS omega · 2026Article
- Direct and in situ examination of LiProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Molecular identification of wines usingFrontiers in chemistry · 2023Article
- Real-time mass spectrometric characterization of the solid-electrolyte interphase of a lithium-ion battery.Nature nanotechnology · 2020Article
- In situ molecular imaging of adsorbed protein films in water indicating hydrophobicity and hydrophilicity.Scientific reports · 2020Article
- Revisiting a classical redox process on a gold electrode by operando ToF-SIMS: where does the gold go?Chemical science · 2019Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In situ liquid secondary ion mass spectrometry (SIMS) enabled by system for analysis at the liquid vacuum interface (SALVI) has proven to be a promising new tool to provide molecular information at solid-liquid and liquid-vacuum interfaces. However, the initial data showed that useful signals in positive ion spectra are too weak to be meaningful in most cases. In addition, it is difficult to obtain strong negative molecular ion signals when m/z>200. These two drawbacks have been the biggest obstacle towards practical use of this new analytical approach. In this study, we report that strong and reliable positive and negative molecular signals are achievable after optimizing the SIMS experimental conditions. Four model systems, including a 1,8-diazabicycloundec-7-ene (DBU)-base switchable ionic liquid, a live Shewanella oneidensis biofilm, a hydrated mammalian epithelia cell, and an electrolyte popularly used in Li ion batteries were studied. A signal enhancement of about two orders of magnitude was obtained in comparison with non-optimized conditions. Therefore, molecular ion signal intensity has become very acceptable for use of in situ liquid SIMS to study solid-liquid and liquid-vacuum interfaces. Graphical Abstract ᅟ.
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Registered trials
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