ArticleBMC evolutionary biology2016
Divergent evolutionary and epidemiological dynamics of cassava mosaic geminiviruses in Madagascar.
Article in BMC evolutionary biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Improving the diagnosis of cassava mosaic begomoviruses using Oxford Nanopore Technology sequencing.Scientific reports · 2025Article
- Towards sustainable management of cassava mosaic disease: The impact of awareness campaigns in Benin.Journal of agriculture and food research · 2025Article
- Macroptilium yellow vein virus (Begomovirus macroptilivenae) associated with Macroptilium plants is geographically structured into divergent subpopulations.Archives of virology · 2025Article
- Reassortments in single-stranded DNA multipartite viruses: Confronting expectations based on molecular constraints with field observations.Virus evolution · 2024Review
- Emergence of Asian endemic begomoviruses as a pandemic threat.Frontiers in plant science · 2022Review
- Genetic Diversity, Pathogenicity and Pseudorecombination of Cucurbit-Infecting Begomoviruses in Malaysia.Plants (Basel, Switzerland) · 2021Article
- Contribution of historical herbarium small RNAs to the reconstruction of a cassava mosaic geminivirus evolutionary history.Scientific reports · 2021Article
- Interspecies Recombination Has Driven the Macroevolution of Cassava Mosaic Begomoviruses.Journal of virology · 2021Article
- Article
- Phenotypic and molecular screenings for determination of cassava mosaic disease (CMD) status in farmers' fields in Ebonyi State, Nigeria.Molecular biology reports · 2021Article
- A cassava protoplast system for screening genes associated with the response to South African cassava mosaic virus.Virology journal · 2020Article
- Article
- Genome wide molecular evolution analysis of begomoviruses reveals unique diversification pattern in coat protein gene of Old World and New World viruses.Virusdisease · 2019Article
- Tomato Yellow Leaf Curl Sardinia Virus, aViruses · 2019Article
- Desmodium mottle virus, the first legumovirus (genus Begomovirus) from East Africa.Archives of virology · 2017Article
- Phylogenetic characterization ofAfrican journal of biotechnology · 2017Article
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13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCassava mosaic disease (CMD) in Madagascar is caused by a complex of at least six African cassava mosaic geminivirus (CMG) species. This provides a rare opportunity for a comparative study of the evolutionary and epidemiological dynamics of distinct pathogenic crop-infecting viral species that coexist within the same environment. The genetic and spatial structure of CMG populations in Madagascar was studied and Bayesian phylogeographic modelling was applied to infer the origins of Madagascan CMG populations within the epidemiological context of related populations situated on mainland Africa and other south western Indian Ocean (SWIO) islands.
resultsThe isolation and analysis of 279 DNA-A and 117 DNA-B sequences revealed the presence in Madagascar of four prevalent CMG species (South African cassava mosaic virus, SACMV; African cassava mosaic virus, ACMV; East African cassava mosaic Kenya virus, EACMKV; and East African cassava mosaic Cameroon virus, EACMCV), and of numerous CMG recombinants that have, to date, only ever been detected on this island. SACMV and ACMV, the two most prevalent viruses, displayed low degrees of genetic diversity and have most likely been introduced to the island only once. By contrast, EACMV-like CMG populations (consisting of East African cassava mosaic virus, EAMCKV, EACMCV and complex recombinants of these) were more diverse, more spatially structured, and displayed evidence of at least three independent introductions from mainland Africa. Although there were no statistically supported virus movement events between Madagascar and the other SWIO islands, at least one mainland African ACMV variant likely originated in Madagascar.
conclusionsOur study highlights both the complexity of CMD in Madagascar, and the distinct evolutionary and spatial dynamics of the different viral species that collectively are associated with this disease. Given that more distinct CMG species and recombinants have been found in Madagascar than any other similarly sized region of the world, the risks of recombinant CMG variants emerging on this island are likely to be higher than elsewhere. Evidence of an epidemiological link between Madagascan and mainland African CMGs suggests that the consequences of such emergence events could reach far beyond the shores of this island.
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