ArticleMicrobiome2016
Post-translational modifications are enriched within protein functional groups important to bacterial adaptation within a deep-sea hydrothermal vent environment.
Article in Microbiome, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Proteome-wide mapping of cysteine persulfidation in deep-sea hyperthermophilic archaea.Extremophiles : life under extreme conditions · 2026Article
- Post translational modifications as biomarkers of soil microbe responses to nano-pesticides.Journal of nanobiotechnology · 2026Review
- Enrichment and Metaproteomic Analysis of Lysine Acetylation in Fecal Microbiome Samples.Methods in molecular biology (Clifton, N.J.) · 2026Article
- An Overview of Mass Spectrometry-Based Methods to Analyze Post-Translational Modifications.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Gut Microbiota Dysbiosis Remodels the Lysine Acetylome of the Mouse Cecum in Early Life.Biology · 2025Article
- The microbiologist's guide to metaproteomics.iMeta · 2025Review
- Elucidating the Mechanisms of Cell-to-Cell Crosstalk in Probiotics Co-culture: A Proteomics Study of Limosilactobacillus reuteri ZJ625 and Ligilactobacillus salivarius ZJ614.Probiotics and antimicrobial proteins · 2024Article
- A Proteogenomic Approach to Unveiling the Complex Biology of the Microbiome.International journal of molecular sciences · 2024Review
- Plant Growth-Promoting Bacteria of Soil: Designing of Consortia Beneficial for Crop Production.Microorganisms · 2023Review
- The Landscape of Global Ocean Microbiome: From Bacterioplankton to Biofilms.International journal of molecular sciences · 2023Review
- Temperature Matters: Bacterial Response to Temperature Change.Journal of microbiology (Seoul, Korea) · 2023Review
- Straw mulch improves soil carbon and nitrogen cycle by mediating microbial community structure and function in the maize field.Frontiers in microbiology · 2023Article
- The role of post-translational modifications in driving abnormal cardiovascular complications at high altitude.Frontiers in cardiovascular medicine · 2022Review
- Propionylation of lysine, a new mechanism of short-chain fatty acids affecting bacterial virulence.American journal of translational research · 2022Review
- Metaproteomics reveals insights into microbial structure, interactions, and dynamic regulation in defined communities as they respond to environmental disturbance.BMC microbiology · 2021Article
- Widespread protein lysine acetylation in gut microbiome and its alterations in patients with Crohn's disease.Nature communications · 2020Article
- Metaproteomic analysis of human gut microbiome in digestive and metabolic diseases.Advances in clinical chemistry · 2020Review
- Nonferrous metal (loid) s mediate bacterial diversity in an abandoned mine tailing impoundment.Environmental science and pollution research international · 2019Article
- China's most typical nonferrous organic-metal facilities own specific microbial communities.Scientific reports · 2018Article
- Regulation, Function, and Detection of Protein Acetylation in Bacteria.Journal of bacteriology · 2017Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-translational modification (PTM) of proteins is one important strategy employed by bacteria for environmental adaptation. However, PTM profiles in deep-sea microbes remain largely unexplored.
resultsWe provide here insight into PTMs in a hydrothermal vent microbial community through integration of metagenomics and metaproteomics. In total, 2919 unique proteins and 1306 unique PTMs were identified, whereas the latter included acetylation, deamination, hydroxylation, methylation, nitrosylation, oxidation, and phosphorylation. These modifications were unevenly distributed among microbial taxonomic and functional categories. A connection between modification types and particular functions was demonstrated. Interestingly, PTMs differed among the orthologous proteins derived from different bacterial groups. Furthermore, proteomic mapping to the draft genome of a Nitrospirae bacterium revealed novel modifications for proteins that participate in energy metabolism, signal transduction, and inorganic ion transport.
conclusionsOur results suggest that PTMs are enriched in specific functions, which would be important for microbial adaptation to extreme conditions of the hydrothermal vent. PTMs in deep-sea are highly diverse and divergent, and much broader investigations are needed to obtain a better understanding of their functional roles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.