Evidence map›Paper›PMID 27600289›Full record

ArticleBiochimica et biophysica acta2016

d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway.

Cheryl S Gradziel, Peter A Jordan, Delilah Jewel, Fay J Dufort, Scott J Miller, Thomas C Chiles, Mary F Roberts

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Cheryl S GradzielDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA. Electronic address: cstrelko@gmail.com.
Peter A JordanDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520, USA. Electronic address: pajordan@ucsd.edu.
Delilah JewelDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA. Electronic address: delilah.jewel@gmail.com.
Fay J DufortDepartment of Biology, Higgins Hall, 140 Commonwealth Avenue, Boston College, Chestnut Hill, MA, USA. Electronic address: faydufort@gmail.com.
Scott J MillerDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520, USA. Electronic address: scott.miller@yale.edu.
Thomas C ChilesDepartment of Biology, Higgins Hall, 140 Commonwealth Avenue, Boston College, Chestnut Hill, MA, USA. Electronic address: chilest@bc.edu.
Mary F RobertsDepartment of Chemistry, Boston College, 2609 Beacon Street, Chestnut Hill, MA 02467, USA. Electronic address: mary.roberts@bc.edu.
Boston College · USYale University · US

Funding

ACTIVATION OF PI-SPECIFIC PHOSPHOLIPASE C ENZYMESR01GM060418 · NIGMS · BOSTON COLLEGE · PI ROBERTS, MARY FEDARKO · 2000 to 2013
$3.1M
NIGMS NIH HHS R01 GM060418
6 · The paper itself

Abstract

Phosphatidylinositol analogs (PIAs) were originally designed to bind competitively to the Akt PH domain and prevent membrane translocation and activation. d-3-Deoxy-dioctanoylphosphatidylinositol (d-3-deoxy-diC

Indexed as

Breast NeoplasmsCell DeathCyclin D1Down-RegulationFemaleHumansMagnetic Resonance SpectroscopyMCF-7 Cellsp38 Mitogen-Activated Protein KinasesPhosphatidic AcidsPhosphatidylinositolsPhosphorylationPleckstrin Homology DomainsProto-Oncogene Proteins c-aktRetinoblastoma ProteinRNA, Small Interfering3-deoxy-dioctanoylphosphatidylinositolCCND1 protein, humanCyclin D1dioctanoylphosphatidic acidp38 Mitogen-Activated Protein KinasesPhosphatidic AcidsPhosphatidylinositolsProto-Oncogene Proteins c-aktRetinoblastoma ProteinRNA, Small Interfering3-Deoxy-phosphatidylinositolD-type cyclin-retinoblastoma protein pathwayField-cycling NMR relaxometryMCF-7 cells

Identifiers

PMID27600289
PMCPMC5115159
OpenAlexW2508957631

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.