ArticleMicroarrays (Basel, Switzerland)2015
Gold Nanoparticles Surface Plasmon Resonance Enhanced Signal for the Detection of Small Molecules on Split-Aptamer Microarrays (Small Molecules Detection from Split-Aptamers).
Article in Microarrays (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Quick methylene blue dye elimination via SDS-Ag nanoparticles catalysts.Scientific reports · 2024Article
- A Metasurface Plasmonic Analysis Platform Combined with Gold Nanoparticles for Ultrasensitive Quantitative Detection of Small Molecules.Biosensors · 2023Article
- Melting Curve Analysis of Aptachains: Adenosine Detection with Internal Calibration.Biosensors · 2021Article
- Combined SPRi Sensor for Simultaneous Detection of Nitrate and Ammonium in Wastewater.Sensors (Basel, Switzerland) · 2021Article
- Hierarchical multifunctional graphene oxide cancer nanotheranostics agent for synchronous switchable fluorescence imaging and chemical therapy.Mikrochimica acta · 2020Article
- Sensing with Nanopores and Aptamers: A Way Forward.Sensors (Basel, Switzerland) · 2020Review
- Plasmon Field-Enhanced Fluorescence Energy Transfer for Hairpin Aptamer Assay Readout.ACS sensors · 2017Article
- Current Trends in Ligand Binding Real-Time Measurement Technologies.The AAPS journal · 2017Review
- Nano-SPRi Aptasensor for the Detection of Progesterone in Buffer.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The detection of small molecules by biosensors remains a challenge for diagnostics in many areas like pharmacology, environment or homeland security. The main difficulty comes from both the low molecular weight and low concentrations of most targets, which generally requires an indirect detection with an amplification or a sandwich procedure. In this study, we combine both strategies as the amplification of Surface Plasmon Resonance imaging (SPRi) signal is obtained by the use of gold nanoparticles and the sequence engineering of split-aptamers, short oligonucleotides strands with strong affinity towards small targets, allows for a sandwich structure. Combining those two strategies, we obtained state-of-the-art results in the limit of detection (LOD = 50 nM) with the model target adenosine. Furthermore, the SPRi detection led on aptamer microarrays paves the way for potential multi-target detections thanks to the multi-probe imaging approach.
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