Evidence map›Paper›PMID 27600055›Full record

Trial reportJournal of human nutrition and dietetics : the official journal of the British Dietetic Association2017

Green tea extract and catechol-O-methyltransferase genotype modify the post-prandial serum insulin response in a randomised trial of overweight and obese post-menopausal women.

A M Dostal, A Arikawa, L Espejo, S Bedell, M S Kurzer, N R Stendell-Hollis

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

A M DostalDivision of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
A ArikawaDepartment of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USA.
L EspejoDepartment of Food Science and Nutrition, University of Minnesota, St Paul, MN, USA.
S BedellDepartment of Food Science and Nutrition, University of Minnesota, St Paul, MN, USA.
M S KurzerDepartment of Food Science and Nutrition, University of Minnesota, St Paul, MN, USA.
N R Stendell-HollisDepartment of Nutrition, Exercise, and Health Sciences, Central Washington University, Ellensburg, WA, USA.
University of Minnesota · USCentral Washington University · USUniversity of North Florida · US

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Green Tea and Reduction of Breast Cancer RiskR01CA127236 · NCI · UNIVERSITY OF MINNESOTA · PI KURZER, MINDY SUSAN · 2008 to 2013
$5.7M
Training Program in Nutrition and CancerT32CA132670 · NCI · UNIVERSITY OF MINNESOTA · PI ANDERSON, KRISTIN ELLEN · 2009 to 2013
$1.6M
NCATS NIH HHS UL1 TR000114NCI NIH HHS R01 CA127236NCI NIH HHS T32 CA132670
6 · The paper itself

Abstract

backgroundGreen tea extract (GTE) may be involved in a favourable post-prandial response to high-carbohydrate meals. The catechol-O-methyltransferase (COMT) genotype may modify these effects. We examined the acute effects of GTE supplementation on the post-prandial response to a high-carbohydrate meal by assessing appetite-associated hormones and glucose homeostasis marker concentrations in women who consumed 843 mg of (-)-epigallocatechin-3-gallate (EGCG) or placebo capsules for 11-12 months.

methodsSixty Caucasian post-menopausal women (body mass index ≥ 25.0 kg m

resultsPlasma leptin, ghrelin and adiponectin did not differ between GTE and placebo at any time point; COMT genotype did not modify these results. Participants randomised to GTE with the high-activity form of COMT (GTE-high COMT) had higher insulin concentrations at time 0, 0.5 and 1.0 h post-meal compared to all COMT groups randomised to placebo. Insulin remained higher in the GTE-high COMT group at 1.5, 2.0 and 2.5 h compared to Placebo-low COMT (P < 0.02). GTE-high COMT had higher insulin concentrations at times 0, 0.5, 1.0, 1.5 and 2.0 h compared to the GTE-low COMT (P ≤ 0.04). Area under the curve measurements of satiety did not differ between GTE and placebo.

conclusionsGTE supplementation and COMT genotype did not alter acute post-prandial responses of leptin, ghrelin, adiponectin or satiety, although it may be involved in post-meal insulinaemic response of overweight and obese post-menopausal women.

Indexed as

AdiponectinAgedAntioxidantsBody Mass IndexCatechinCatechol O-MethyltransferaseDietary SupplementsDouble-Blind MethodFemaleGenotypeGhrelinHumansInsulinLeptinMiddle AgedObesityAdiponectinAntioxidantsCatechinCatechol O-MethyltransferaseCOMT protein, humanepigallocatechin gallateGhrelinInsulinLeptinPlant ExtractsTeagreen teainsulin sensitivityobesitypost-menopausal womenpost-prandial responsesatiety

Identifiers

PMID27600055
PMCPMC5340619
OpenAlexW2515718703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.