Evidence map›Paper›PMID 27599974›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2017

Real-world use of fractional flow reserve in Germany: results of the prospective ALKK coronary angiography and PCI registry.

Tobias Härle, Uwe Zeymer, Matthias Hochadel, Ralf Zahn, Sebastian Kerber, Bernhard Zrenner, Volker Schächinger, Bernward Lauer, Thorsten Runde, Albrecht Elsässer

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.

  1. Guideline
  2. Use of Intracoronary Pressure Wire Assessment and Association With Outcomes: Insights From the British Cardiovascular Intervention Society National Database.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Article
  3. Article
  4. Automated stenosis estimation of coronary angiographies using end-to-end learning.The international journal of cardiovascular imaging · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Use of coronary physiology to guide revascularization in clinical practice: results of the F(FR)Clinical research in cardiology : official journal of the German Cardiac Society · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Fractional flow reserve as the standard of reference: All that glistens is not gold.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Tobias HärleKlinik für Kardiologie, Klinikum Oldenburg gGmbH, European Medical School Oldenburg-Groningen, Carl von Ossietzky Universität Oldenburg, Rahel-Straus-Str. 10, 26133, Oldenburg, Germany. t.haerle@gmx.de.ORCID http://orcid.org/0000-0002-0492-7044
Uwe ZeymerMedizinische Klinik B, Klinikum Ludwigshafen, Ludwigshafen, Germany.
Matthias HochadelStiftung Institut für Herzinfarktforschung, Ludwigshafen, Germany.
Ralf ZahnMedizinische Klinik B, Klinikum Ludwigshafen, Ludwigshafen, Germany.
Sebastian KerberKlinik für Kardiologie, Herz- und Gefäß-Klinik GmbH, Bad Neustadt a. d., Haale, Germany.
Bernhard ZrennerKrankenhaus Landshut-Achdorf, Medizinische Klinik I, Landshut, Germany.
Volker SchächingerKlinikum Fulda, Medizinische Klinik I, Fulda, Germany.
Bernward LauerKlinik für Kardiologie, Zentralklinik Bad Berka, Bad Berka, Germany.
Thorsten RundeKlinikum Wetzlar, Medizinische Klinik I, Wetzlar, Germany.
Albrecht ElsässerKlinik für Kardiologie, Klinikum Oldenburg gGmbH, European Medical School Oldenburg-Groningen, Carl von Ossietzky Universität Oldenburg, Rahel-Straus-Str. 10, 26133, Oldenburg, Germany.
Carl von Ossietzky Universität Oldenburg · DEStiftung Institut für Herzinfarktforschung · DEKlinikum Fulda · DEKlinikum Ludwigshafen · DERhön-Klinikum · DEUniversity of Applied Sciences Landshut · DEZentralklinik Bad Berka · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is growing evidence for beneficial prognostic and economic effects of FFR-guided treatment of stable coronary artery disease. We sought to evaluate the real-world use of FFR measurements in patients undergoing elective coronary angiography. METHODS AND

resultsWe analyzed the data of the prospective ALKK coronary angiography and PCI registry including data of 38 hospitals from January 2010 to December 2013. A total of 100,977 patients undergoing coronary angiography were included. In 3240 patients (3.2 %) intracoronary pressure measurement was performed. There was a wide range of use of FFR measurement in the different analyzed ALKK hospitals from 0.1 to 8.8 % in elective patients with suspected or known coronary artery disease (median 2.7 %, quartiles 0.9 and 5.3 %), with a successive increase of use over time during the study period. Overall, it was performed in 3.2 % of coronary angiographies. Use in patients with three-vessel disease (2.5 %) and recommendation for bypass surgery (1.6 %) was less frequent. In procedures without PCI, dose area product was higher in the FFR group (2641 cGy × cm

conclusionsThe use of FFR measurement was very heterogeneous between different hospitals and in general relatively low, in particular in patients with multivessel disease or recommendation for bypass surgery, but there was a positive trend during the study period. Technically, FFR measurement was not associated with an increased periprocedural complication rate.

Indexed as

Coronary AngiographyFractional Flow Reserve, MyocardialPercutaneous Coronary InterventionAgedCardiac CatheterizationCardiac CathetersCoronary StenosisCoronary VesselsFemaleGermanyHumansMaleMiddle AgedPractice Patterns, Physicians'Predictive Value of TestsRadiation DosageCoronary artery bypassCoronary artery diseaseFFRFractional flow reservePercutaneous coronary intervention

Identifiers

PMID27599974
OpenAlexW2519295564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.