ReviewWiley interdisciplinary reviews. Systems biology and medicine2016
Blood type biochemistry and human disease.
Review in Wiley interdisciplinary reviews. Systems biology and medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 4 syntheses or guidelines pooled it, 184 citations in OpenAlex.
- Relationship between ABO blood group antigens and Rh factor with breast cancer: A systematic review and meta-analysis.Oncotarget · 2025Pooled it
- Pooled it
- Relationships of ABO and Rhesus blood groups with type 2 diabetes mellitus: a systematic review and meta-analysis.The Journal of international medical research · 2022Pooled it
- The Association Between ABO Blood Group and Preeclampsia: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- The Association Between ABO Blood Groups and Neonatal Clinical Outcomes Among Infants Admitted to the Neonatal Intensive Care Unit of Imam Khomeini Hospital in Ahvaz, Iran, During 2023-2024: A Retrospective Descriptive Study.Health science reports · 2026Article
- Prevalence of ABO Blood Groups and Their Relationship with Vascular Access Thrombosis and Mortality in Hemodialysis Patients.Medicina (Kaunas, Lithuania) · 2026Article
- Observational
- Distribution characteristics of dyslipidemia in ABO blood groups in Suburbs of Shanghai, China: A cross-sectional study.Science progress · 2026Article
- ABO Incongruency Increases Risk for Necrotizing Enterocolitis in Preterm Neonates.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026Article
- Association between ABO/Rh blood groups and transfusion-transmitted infections among Turkish blood donors: a comprehensive demographic analysis (2015-2021).BMC infectious diseases · 2026Article
- ABO gene polymorphisms: a molecular bridge linking disease susceptibility to therapeutic outcomes.Frontiers in medicine · 2026Review
- Association of ABO Blood Groups with HPV Genotypes and Cervical Lesions in HPV-Positive Women.International journal of women's health · 2026Article
- Association of ABO Blood Groups with Osteoporotic Hip Fracture Susceptibility in Chinese Adults.Calcified tissue international · 2025Article
- B blood type indicates poorer overall survival in patients with severe burn injuries: a case-control study.Annals of medicine · 2025Article
- ABO blood group and Rhesus factor as potential markers in papillary thyroid cancer: a retrospective comparative analysis (2015-2023).Langenbeck's archives of surgery · 2025Article
- A genome-wide association study in 10,000 individuals links plasma N-glycome to liver disease and anti-inflammatory proteins.Nature communications · 2025Article
- Article
- Merging High-Throughput, Amplicon-Based Second and Third Generation Sequencing Data: An Integrative and Modular Data Analysis Framework for Haplotype Prediction and Output Evaluation.International journal of molecular sciences · 2025Article
- ABO blood group antigens in saliva - A cross sectional study.Bioinformation · 2025Article
- Relationship between Condylar and Ramal Asymmetries and ABO and Rh Blood GroupsCurrent medical imaging · 2025Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Associations between blood type and disease have been studied since the early 1900s when researchers determined that antibodies and antigens are inherited. In the 1950s, the chemical identification of the carbohydrate structure of surface antigens led to the understanding of biosynthetic pathways. The blood type is defined by oligosaccharide structures, which are specific to the antigens, thus, blood group antigens are secondary gene products, while the primary gene products are various glycosyltransferase enzymes that attach the sugar molecules to the oligosaccharide chain. Blood group antigens are found on red blood cells, platelets, leukocytes, plasma proteins, certain tissues, and various cell surface enzymes, and also exist in soluble form in body secretions such as breast milk, seminal fluid, saliva, sweat, gastric secretions, urine, and amniotic fluid. Recent advances in technology, biochemistry, and genetics have clarified the functional classifications of human blood group antigens, the structure of the A, B, H, and Lewis determinants and the enzymes that produce them, and the association of blood group antigens with disease risks. Further research to identify differences in the biochemical composition of blood group antigens, and the relationship to risks for disease, can be important for the identification of targets for the development of nutritional intervention strategies, or the identification of druggable targets. WIREs Syst Biol Med 2016, 8:517-535. doi: 10.1002/wsbm.1355 For further resources related to this article, please visit the WIREs website.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.