ArticleScientific reports2016
Gene expression clines reveal local adaptation and associated trade-offs at a continental scale.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Evolutionary Dynamics of Gene Expression During Thermal Adaptation in Drosophila subobscura.Genome biology and evolution · 2026Article
- Facultative polyandry under heat stress and the evolutionary potential for climate-driven shifts in mating systems.Heredity · 2025Article
- Metabolic differentiation of brushtail possum populations resistant and susceptible to plant toxins revealed via differential gene expression.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Global comparative transcriptomes uncover novel and population-specific gene expression in esophageal squamous cell carcinoma.Infectious agents and cancer · 2023Article
- Population differences in Chinook salmon (Ecology and evolution · 2021Article
- Parallel gene expression evolution in natural and laboratory evolved populations.Molecular ecology · 2021Article
- The Evolution of Phenotypic Plasticity in Response to Temperature Stress.Genome biology and evolution · 2020Article
- Review
- Article
- A simple genetic basis of adaptation to a novel thermal environment results in complex metabolic rewiring in Drosophila.Genome biology · 2018Article
- Systems genetic analysis of inversion polymorphisms in the malaria mosquitoProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Patterns of geographic variation of thermal adapted candidate genes in Drosophila subobscura sex chromosome arrangements.BMC evolutionary biology · 2018Article
- Elevated temperatures have sex-specific effects on nuptial gift behavior.Behavioral ecology : official journal of the International Society for Behavioral EcologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Local adaptation, where fitness in one environment comes at a cost in another, should lead to spatial variation in trade-offs between life history traits and may be critical for population persistence. Recent studies have sought genomic signals of local adaptation, but often have been limited to laboratory populations representing two environmentally different locations of a species' distribution. We measured gene expression, as a proxy for fitness, in males of Drosophila subobscura, occupying a 20° latitudinal and 11 °C thermal range. Uniquely, we sampled six populations and studied both common garden and semi-natural responses to identify signals of local adaptation. We found contrasting patterns of investment: transcripts with expression positively correlated to latitude were enriched for metabolic processes, expressed across all tissues whereas negatively correlated transcripts were enriched for reproductive processes, expressed primarily in testes. When using only the end populations, to compare our results to previous studies, we found that locally adaptive patterns were obscured. While phenotypic trade-offs between metabolic and reproductive functions across widespread species are well-known, our results identify underlying genetic and tissue responses at a continental scale that may be responsible for this. This may contribute to understanding population persistence under environmental change.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.